2f8a: Difference between revisions
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==Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1== | ==Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1== | ||
<StructureSection load='2f8a' size='340' side='right' caption='[[2f8a]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='2f8a' size='340' side='right'caption='[[2f8a]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2f8a]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2f8a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F8A FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f8a OCA], [https://pdbe.org/2f8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f8a RCSB], [https://www.ebi.ac.uk/pdbsum/2f8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f8a ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/GPX1_HUMAN GPX1_HUMAN] Protects the hemoglobin in erythrocytes from oxidative breakdown. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/2f8a_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/2f8a_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f8a ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| Line 25: | Line 25: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Edwards A]] | |||
[[Category: Edwards | [[Category: Gileadi O]] | ||
[[Category: Gileadi | [[Category: Johansson C]] | ||
[[Category: Johansson | [[Category: Kavanagh KL]] | ||
[[Category: Kavanagh | [[Category: Oppermann U]] | ||
[[Category: Oppermann | [[Category: Smee C]] | ||
[[Category: Sundstrom M]] | |||
[[Category: Smee | [[Category: Weigelt J]] | ||
[[Category: Sundstrom | [[Category: Von Delft F]] | ||
[[Category: Weigelt | |||
[[Category: | |||
Latest revision as of 12:22, 30 August 2023
Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1
Structural highlights
FunctionGPX1_HUMAN Protects the hemoglobin in erythrocytes from oxidative breakdown. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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