8h9f: Difference between revisions

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-'''Unreleased structure'''
-The entry 8h9f is ON HOLD
+==Human ATP synthase state 1 subregion 3==
+<StructureSection load='8h9f' size='340' side='right'caption='[[8h9f]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8h9f]] is a 17 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8H9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8H9F FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.69&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PH:1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE'>3PH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8h9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8h9f OCA], [https://pdbe.org/8h9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8h9f RCSB], [https://www.ebi.ac.uk/pdbsum/8h9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8h9f ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/AT5G1_HUMAN AT5G1_HUMAN] Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Biological energy currency ATP is produced by F(1)F(o)-ATP synthase. However, the molecular mechanism for human ATP synthase action remains unknown. Here, we present snapshot images for three main rotational states and one substate of human ATP synthase using cryoelectron microscopy. These structures reveal that the release of ADP occurs when the beta subunit of F(1)F(o)-ATP synthase is in the open conformation, showing how ADP binding is coordinated during synthesis. The accommodation of the symmetry mismatch between F(1) and F(o) motors is resolved by the torsional flexing of the entire complex, especially the gamma subunit, and the rotational substep of the c subunit. Water molecules are identified in the inlet and outlet half-channels, suggesting that the proton transfer in these two half-channels proceed via a Grotthus mechanism. Clinically relevant mutations are mapped to the structure, showing that they are mainly located at the subunit-subunit interfaces, thus causing instability of the complex.
-Authors: Lai, Y., Zhang, Y., Liu, F., Gao, Y., Gong, H., Rao, Z.
+Structure of the human ATP synthase.,Lai Y, Zhang Y, Zhou S, Xu J, Du Z, Feng Z, Yu L, Zhao Z, Wang W, Tang Y, Yang X, Guddat LW, Liu F, Gao Y, Rao Z, Gong H Mol Cell. 2023 Jun 15;83(12):2137-2147.e4. doi: 10.1016/j.molcel.2023.04.029. , Epub 2023 May 26. PMID:37244256<ref>PMID:37244256</ref>
-Description: Human ATP synthase state 1 subregion 3
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Gong, H]]
+<div class="pdbe-citations 8h9f" style="background-color:#fffaf0;"></div>
-[[Category: Gao, Y]]
+== References ==
-[[Category: Zhang, Y]]
+<references/>
-[[Category: Liu, F]]
+__TOC__
-[[Category: Rao, Z]]
+</StructureSection>
-[[Category: Lai, Y]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Gao Y]]
+[[Category: Gong H]]
+[[Category: Lai Y]]
+[[Category: Liu F]]
+[[Category: Rao Z]]
+[[Category: Zhang Y]]