Phosphoglycerate dehydrogenase: Difference between revisions
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<StructureSection load='' size='350' side='right' caption='Phosphoglycerate dehydrogenase complex with hydroxypyruvic acid phosphate and tartarate (PDB entry [[3ddn]])' scene='49/491889/Cv/1'> | |||
<StructureSection load=' | |||
== Function == | == Function == | ||
'''Phosphoglycerate dehydrogenase''' (PGDH) catalyzes the conversion of 3-phosphoglycerate into 3-phosphohydroxypyruvate. This is the first step of serine biosynthesis<ref>PMID:11567059</ref>. NAD is used as cofactor. | '''Phosphoglycerate dehydrogenase''' (PGDH) catalyzes the conversion of 3-phosphoglycerate into 3-phosphohydroxypyruvate. This is the first step of serine biosynthesis<ref>PMID:11567059</ref>. NAD is used as cofactor. | ||
See also:[[3-Phosphoglycerates: serine, glycine, cysteine]] | |||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
The active site of ''Mycobacterium tuberculosis'' located in the cleft between the substrate and the NAD-binding domains contains the catalytic dyad Glu:His and the substrate<ref>PMID:18627175</ref>. | The active site of ''Mycobacterium tuberculosis'' PGDH located in the cleft between the substrate and the NAD-binding domains contains the <scene name='49/491889/Cv/3'>catalytic dyad Glu:His and the substrate</scene><ref>PMID:18627175</ref>. | ||
See [[Rossmann fold]]. | See [[Rossmann fold]]. | ||
</StructureSection> | </StructureSection> | ||
==3D structures of phosphoglycerate dehydrogenase== | ==3D structures of phosphoglycerate dehydrogenase== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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*Phosphoglycerate dehydrogenase binary complex | *Phosphoglycerate dehydrogenase binary complex | ||
**[[2g76]], [[7cvp]] - h3-PGDH + NAD – human<br /> | |||
**[[5n53]], [[5nzo]], [[5nzp]], [[5nzq]], [[5ofv]], [[5ofw]], [[7ewh]] – h3-PGDH + drug<br /> | |||
**[[5ofm]] – h3-PGDH + amino-methyl-indole<br /> | |||
**[[7va1]] – h3-PGDH + thiazole derivative<br /> | |||
**[[7dkm]] – h3-PGDH + inhibitor<br /> | |||
**[[1sc6]], [[2p9c]], [[2p9e]], [[2p9g]] - EcPGDH (mutant) + NAD – ''Escherichia coli''<br /> | **[[1sc6]], [[2p9c]], [[2p9e]], [[2p9g]] - EcPGDH (mutant) + NAD – ''Escherichia coli''<br /> | ||
**[[1yba]] - EcPGDH + NAD<br /> | **[[1yba]] - EcPGDH + NAD<br /> | ||
**[[1wwk]] - PGDH + NAD – ''Pyrococcus horikoshii''<br /> | **[[1wwk]] - PGDH + NAD – ''Pyrococcus horikoshii''<br /> | ||
**[[2ekl]] - PGDH + NAD – ''Sulfolobus tokodaii''<br /> | **[[2ekl]] - PGDH + NAD – ''Sulfolobus tokodaii''<br /> | ||
**[[3ddn]] - MtPGDH + hydroxypyruvic acid phosphate | **[[3ddn]] - MtPGDH + hydroxypyruvic acid phosphate | ||
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*Phosphoglycerate dehydrogenase ternary complex | *Phosphoglycerate dehydrogenase ternary complex | ||
**[[5n6c]] – h3-PGDH + NAD + tartrate<br /> | |||
**[[6cwa]] – h3-PGDH + NAD + 3PG<br /> | |||
**[[6plf]], [[6plg]] – h3-PGDH + indole amide derivative<br /> | |||
**[[6rih]], [[6rj2]], [[6rj3]], [[6rj5]], [[6rj6]] – h3-PGDH + inhibitor<br /> | |||
**[[1psd]] - EcPGDH + serine + NAD <br /> | **[[1psd]] - EcPGDH + serine + NAD <br /> | ||
**[[2pa3]] - EcPGDH (mutant) + serine + NAD | **[[2pa3]] - EcPGDH (mutant) + serine + NAD<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||