Phosphoglycerate dehydrogenase: Difference between revisions

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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-<applet load="2g76" size="400" color="white" frame="true" align="right" caption="Human phosphoglycerate dehydrogenase dimer complex with malate and cofactor NAD  [[2g76]]" /><!--
+<StructureSection load='' size='350' side='right' caption='Phosphoglycerate dehydrogenase complex with hydroxypyruvic acid phosphate and tartarate (PDB entry [[3ddn]])' scene='49/491889/Cv/1'>
-Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
+== Function ==
-Or use the four-green-boxes-button to insert scrollable text adjacent
-to a Jmol applet. Check out the other buttons as well!
--->
-'''Phosphoglycerate dehydrogenase''' (PGDH) catalyzes the conversion of 3-phosphoglycerate into 3-phosphohydroxypyruvate.  This is the first step of serine biosynthesis.  NAD is used as cofactor.  In some cancer cells there is an elevation in PGDH level.
+'''Phosphoglycerate dehydrogenase''' (PGDH) catalyzes the conversion of 3-phosphoglycerate into 3-phosphohydroxypyruvate.  This is the first step of serine biosynthesis<ref>PMID:11567059</ref>.  NAD is used as cofactor.
+See also:[[3-Phosphoglycerates: serine, glycine, cysteine]]
+== Relevance ==
+In some cancer cells there is an elevation in PGDH level and hence an increase in serine biosynthesis<ref>PMID:26831078</ref>.
+== Structural highlights ==
+The active site of ''Mycobacterium tuberculosis'' PGDH located in the cleft between the substrate and the NAD-binding domains contains the <scene name='49/491889/Cv/3'>catalytic dyad Glu:His and the substrate</scene><ref>PMID:18627175</ref>.
+See [[Rossmann fold]].
+</StructureSection>
 ==3D structures of phosphoglycerate dehydrogenase==
-===PDGH===
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
-[[1ygy]], [[3dc2]] – MtPGDH – ''Mycobacterium tuberculosis''<br />
+*'''Phosphoglycerate dehydrogenase'''
-[[3evt]] - PGDH – ''Lactobacillus plantarum''<br />
-[[3gg9]] - PGDH – ''Ralstonia solanacearum''<br />
-[[3k5p]] - PGDH (mutant) – ''Brucella melitensis''
-===PGDH binary complex===
+**[[1ygy]], [[3dc2]] – MtPGDH – ''Mycobacterium tuberculosis''<br />
+**[[3evt]] - PGDH – ''Lactobacillus plantarum''<br />
+**[[3gg9]] - PGDH – ''Ralstonia solanacearum''<br />
+**[[3k5p]] - PGDH (mutant) – ''Brucella melitensis''
-[[1sc6]], [[2p9c]], [[2p9e]], [[2p9g]] - EcPGDH (mutant) + NAD – ''Escherichia coli''<br />
+*Phosphoglycerate dehydrogenase binary complex
-[[1yba]] - EcPGDH + NAD<br />
-[[1wwk]] - PGDH + NAD – ''Pyrococcus horikoshii''<br />
-[[2g76]] - PGDH + NAD – human<br />
-[[2ekl]] - PGDH + NAD – ''Sulfolobus tokodaii''<br />
-[[3ddn]] - MtPGDH + hydroxypyruvic acid phosphate
-===PGDH ternary complex===
+**[[2g76]], [[7cvp]] - h3-PGDH + NAD – human<br />
+**[[5n53]], [[5nzo]], [[5nzp]], [[5nzq]], [[5ofv]], [[5ofw]], [[7ewh]] – h3-PGDH + drug<br />
+**[[5ofm]] – h3-PGDH + amino-methyl-indole<br />
+**[[7va1]] – h3-PGDH + thiazole derivative<br />
+**[[7dkm]] – h3-PGDH + inhibitor<br />
+**[[1sc6]], [[2p9c]], [[2p9e]], [[2p9g]] - EcPGDH (mutant) + NAD – ''Escherichia coli''<br />
+**[[1yba]] - EcPGDH + NAD<br />
+**[[1wwk]] - PGDH + NAD – ''Pyrococcus horikoshii''<br />
+**[[2ekl]] - PGDH + NAD – ''Sulfolobus tokodaii''<br />
+**[[3ddn]] - MtPGDH + hydroxypyruvic acid phosphate
-[[1psd]] - EcPGDH + serine + NAD <br />
+*Phosphoglycerate dehydrogenase ternary complex
-[[2pa3]] - EcPGDH (mutant) + serine + NAD
+**[[5n6c]] – h3-PGDH + NAD + tartrate<br />
+**[[6cwa]] – h3-PGDH + NAD + 3PG<br />
+**[[6plf]], [[6plg]] – h3-PGDH + indole amide derivative<br />
+**[[6rih]], [[6rj2]], [[6rj3]], [[6rj5]], [[6rj6]] – h3-PGDH + inhibitor<br />
+**[[1psd]] - EcPGDH + serine + NAD <br />
+**[[2pa3]] - EcPGDH (mutant) + serine + NAD<br />
+}}
+== References ==
+<references/>
 [[Category:Topic Page]]