Pheromone binding protein: Difference between revisions
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<StructureSection load='3bfa' size='340' side='right' caption='Pheromone binding protein of honey bee complex with pheromone (PDB code [[3bfa]]).' scene=''> | |||
__TOC__ | |||
==Introduction== | ==Introduction== | ||
'''Pheromone binding proteins''' [http://en.wikipedia.org/wiki/Pheromone_binding_protein (PBP)] are type of Odorant binding proteins [http://en.wikipedia.org/wiki/Odorant-binding_protein (OBP)] - soluble proteins mediating the early stages of volatiles detection in both insects and vertebrates<ref>DOI:10.3389/fphys.2014.00320</ref>. The volatiles (pheromones and other small hydrophobic molecules) are solubilized by the OBPs and activate the chemoreceptors. | |||
The volatiles (pheromones and other small hydrophobic molecules) are solubilized by the OBPs and activate the chemoreceptors. | |||
As a model protein of this family we will further describe the well investigated Pheromone binding protein of the honey bee, ASP1. | As a model protein of this family we will further describe the well investigated Pheromone binding protein of the honey bee, ASP1. | ||
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== Interaction with the ligand 9-ODA== | == Interaction with the ligand 9-ODA== | ||
<scene name='60/609542/9-oda/3'>9-ODA</scene> | One of the main components of the QMP <scene name='60/609542/9-oda/3'>9-ODA</scene>, is binding to the protein binding site along with a <scene name='60/609542/Glycerol/2'>glycerol molecule</scene>.The carboxyl end of 9-ODA points towards the solvent, and has no bonds with residues of the protein. The residues in the binding site are <scene name='60/609542/Binding_site/3'>hydrophobic</scene>, and the connection between 9-ODA and ASP1 involve hydrogen bonds. | ||
The carboxyl end of 9-ODA points towards the solvent, and has no bonds with residues of the protein. The residues in the binding site are <scene name='60/609542/Binding_site/3'>hydrophobic</scene> | </StructureSection> | ||
, and the connection between 9-ODA and ASP1 involve hydrogen bonds. | |||
==3D structures of pheromone-binding protein== | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
* Pheromone binding protein | |||
**[[2h8v]], [[3bjh]], [[3cab]], [[3cdn]], [[3cz2]] – bPBP residues 26-144 – honey bee<br /> | |||
**[[3d73]], [[3d74]], [[3d75]], [[3d76]], [[3d77]], [[3d78]] - bPBP residues 26-144 (mutant)<br /> | |||
**[[1dqe]], [[2fjy]] – sPBP – silkworm<br /> | |||
**[[1xfr]] – sPBP – NMR<br /> | |||
**[[1gm0]] – sPBP (mutant) – NMR<br /> | |||
**[[1qwv]], [[1two]], [[2jpo]], [[6um9]] – mPBP – moth - NMR<br /> | |||
**[[6vq5]] – mPBP <br /> | |||
**[[7uo6]] – PBP2 – corn borer - NMR<br /> | |||
**[[7vw8]], [[7vw9]] – bwPBP1 - bollworm<br /> | |||
* Pheromone binding protein complex | |||
**[[3bfa]], [[3bfb]], [[3bfh]], [[3cyz]] – bPBP residues 26-144 + pheromone<br /> | |||
**[[3cz0]], [[3cz1]] - bPBP residues 26-144 + N-butyl benzene sulfonamide<br /> | |||
**[[3fe6]], [[3fe8]], [[3fe9]] - bPBP residues 26-144 + methyldotetracontane<br /> | |||
**[[2p70]] – sPBP + odorant<br /> | |||
**[[2p71]] – sPBP + iodohexadecane<br /> | |||
**[[4inw]], [[4inx]] – PBP + hexadecadienal – ''Amyelois transitella''<br /> | |||
**[[7vwa]] – bwPBP1 + odorant <br /> | |||
}} | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category: Topic Page]] | |||