2y7z: Difference between revisions

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-[[Image:2y7z.jpg|left|200px]]
-<!--
+==Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs==
-The line below this paragraph, containing "STRUCTURE_2y7z", creates the "Structure Box" on the page.
+<StructureSection load='2y7z' size='340' side='right'caption='[[2y7z]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2y7z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y7Z FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C0Z:6-CHLORO-N-[(3S)-1-[(1S)-1-DIMETHYLAMINO-2,3-DIHYDRO-1H-INDEN-5-YL]-2-OXO-PYRROLIDIN-3-YL]NAPHTHALENE-2-SULFONAMIDE'>C0Z</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-{{STRUCTURE_2y7z|  PDB=2y7z  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7z OCA], [https://pdbe.org/2y7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y7z RCSB], [https://www.ebi.ac.uk/pdbsum/2y7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y7z ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The rational design, syntheses and evaluation of potent sulfonamidopyrrolidin-2-one-based factor Xa inhibitors incorporating aminoindane and phenylpyrrolidine P4 motifs are described. These series delivered highly potent anticoagulant compounds with excellent oral pharmacokinetic profiles; however, significant time dependant P450 inhibition was an issue for the aminoindane series, but this was not observed with the phenylpyrrolidine motif, which produced candidate quality molecules with potential for once-daily oral dosing in humans.
-===STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH AMINOINDANE AND PHENYLPYRROLIDINE P4 MOTIFS===
+Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs.,Young RJ, Adams C, Blows M, Brown D, Burns-Kurtis CL, Chan C, Chaudry L, Convery MA, Davies DE, Exall AM, Foster G, Harling JD, Hortense E, Irvine S, Irving WR, Jackson S, Kleanthous S, Pateman AJ, Patikis AN, Roethka TJ, Senger S, Stelman GJ, Toomey JR, West RI, Whittaker C, Zhou P, Watson NS Bioorg Med Chem Lett. 2011 Mar 15;21(6):1582-7. Epub 2011 Feb 1. PMID:21349710<ref>PMID:21349710</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2y7z" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_21349710}}, adds the Publication Abstract to the page
+*[[Factor Xa|Factor Xa]]
-(as it appears on PubMed at http://www.pubmed.gov), where 21349710 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_21349710}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[2y7z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7Z OCA].
-==Reference==
-<ref group="xtra">PMID:21349710</ref><references group="xtra"/>
-[[Category: Coagulation factor Xa]]
 [[Category: Homo sapiens]]
-[[Category: Adams, C.]]
+[[Category: Large Structures]]
-[[Category: Blows, M.]]
+[[Category: Adams C]]
-[[Category: Brown, D.]]
+[[Category: Blows M]]
-[[Category: Burns-Kurtis, C L.]]
+[[Category: Brown D]]
-[[Category: Chan, C.]]
+[[Category: Burns-Kurtis CL]]
-[[Category: Chaudry, L.]]
+[[Category: Chan C]]
-[[Category: Convery, M A.]]
+[[Category: Chaudry L]]
-[[Category: Davies, D E.]]
+[[Category: Convery MA]]
-[[Category: Exall, A M.]]
+[[Category: Davies DE]]
-[[Category: Foster, G.]]
+[[Category: Exall AM]]
-[[Category: Harling, J D.]]
+[[Category: Foster G]]
-[[Category: Hortense, E.]]
+[[Category: Harling JD]]
-[[Category: Irvine, S.]]
+[[Category: Hortense E]]
-[[Category: Irving, W R.]]
+[[Category: Irvine S]]
-[[Category: Jackson, S.]]
+[[Category: Irving WR]]
-[[Category: Kleanthous, S.]]
+[[Category: Jackson S]]
-[[Category: Pateman, A J.]]
+[[Category: Kleanthous S]]
-[[Category: Patikis, A N.]]
+[[Category: Pateman AJ]]
-[[Category: Roethka, T J.]]
+[[Category: Patikis AN]]
-[[Category: Senger, S.]]
+[[Category: Roethka TJ]]
-[[Category: Stelman, G J.]]
+[[Category: Senger S]]
-[[Category: Toomey, J R.]]
+[[Category: Stelman GJ]]
-[[Category: Watson, N S.]]
+[[Category: Toomey JR]]
-[[Category: West, R I.]]
+[[Category: Watson NS]]
-[[Category: Whittaker, C.]]
+[[Category: West RI]]
-[[Category: Young, R J.]]
+[[Category: Whittaker C]]
-[[Category: Zhou, P.]]
+[[Category: Young RJ]]
+[[Category: Zhou P]]