2y0f: Difference between revisions

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-[[Image:2y0f.png|left|200px]]
-<!--
+==STRUCTURE OF GCPE (IspG) FROM THERMUS THERMOPHILUS HB27==
-The line below this paragraph, containing "STRUCTURE_2y0f", creates the "Structure Box" on the page.
+<StructureSection load='2y0f' size='340' side='right'caption='[[2y0f]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2y0f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y0F FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
-{{STRUCTURE_2y0f|  PDB=2y0f  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y0f OCA], [https://pdbe.org/2y0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y0f RCSB], [https://www.ebi.ac.uk/pdbsum/2y0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y0f ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ISPG_THET2 ISPG_THET2]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Isoprenoids are biosynthesized via the mevalonate or the 2-C-methyl-d-erythritol-4-phosphate (MEP) pathways the latter being used by most pathogenic bacteria, some parasitic protozoa, plant plastids, but not by animals. We determined the X-ray structure of the homodimeric [4Fe-4S] cluster carrying E-1-hydroxy-2-methyl-but-2-enyl-4-diphosphate synthase (GcpE) of Thermus thermophilus which catalyzes the penultimate reaction of the MEP pathway and is therefore an attractive target for drug development. The [4Fe-4S] cluster ligated to three cysteines and one glutamate is encapsulated at the intersubunit interface. The substrate binding site lies in front of an (alphabeta)(8) barrel. The great [4Fe-4S] cluster-substrate distance implicates large-scale domain rearrangements during the reaction cycle. STRUCTURED SUMMARY: gcpEbinds to gcpE by x-ray crystallography (View interaction).
-===STRUCTURE OF GCPE (ISPG) FROM THERMUS THERMOPHILUS HB27===
+Structure of the E-1-hydroxy-2-methyl-but-2-enyl-4-diphosphate synthase (GcpE) from Thermus thermophilus.,Rekittke I, Nonaka T, Wiesner J, Demmer U, Warkentin E, Jomaa H, Ermler U FEBS Lett. 2010 Dec 15. PMID:21167158<ref>PMID:21167158</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2y0f" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_21167158}}, adds the Publication Abstract to the page
+*[[IspG|IspG]]
-(as it appears on PubMed at http://www.pubmed.gov), where 21167158 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_21167158}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-[[2y0f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y0F OCA].
+[[Category: Thermus thermophilus HB27]]
+[[Category: Demmer U]]
-==Reference==
+[[Category: Ermler U]]
-<ref group="xtra">PMID:21167158</ref><references group="xtra"/>
+[[Category: Jomaa H]]
-[[Category: Thermus thermophilus]]
+[[Category: Nonaka T]]
-[[Category: Demmer, U.]]
+[[Category: Rekittke I]]
-[[Category: Ermler, U.]]
+[[Category: Warkentin E]]
-[[Category: Jomaa, H.]]
+[[Category: Wiesner J]]
-[[Category: Nonaka, T.]]
-[[Category: Rekittke, I.]]
-[[Category: Warkentin, E.]]
-[[Category: Wiesner, J.]]