2f3k: Difference between revisions

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-[[Image:2f3k.png|left|200px]]
-{{STRUCTURE_2f3k|  PDB=2f3k  |  SCENE=  }}
+==Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease==
+<StructureSection load='2f3k' size='340' side='right'caption='[[2f3k]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2f3k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F3K FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.599&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RO1:(3S,4AS,8AS)-N-(TERT-BUTYL)-2-[(3S)-3-({3-(METHYLSULFONYL)-N-[(PYRIDIN-3-YLOXY)ACETYL]-L-VALYL}AMINO)-2-OXO-4-PHENYLBUTYL]DECAHYDROISOQUINOLINE-3-CARBOXAMIDE'>RO1</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3k OCA], [https://pdbe.org/2f3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f3k RCSB], [https://www.ebi.ac.uk/pdbsum/2f3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3k ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/O38708_9HIV1 O38708_9HIV1]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f3/2f3k_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f3k ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+In our previous crystallographic studies of human immunodeficiency virus type 1 (HIV-1) protease-substrate complexes, we described a conserved "envelope" that appears to be important for substrate recognition and the selection of drug-resistant mutations. In this study, the complex of HIV-1 protease with the inhibitor RO1 was determined and comparison with the substrate envelope provides a rationale for mutational patterns.
-===Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease===
+Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease.,Prabu-Jeyabalan M, King NM, Nalivaika EA, Heilek-Snyder G, Cammack N, Schiffer CA Antimicrob Agents Chemother. 2006 Apr;50(4):1518-21. PMID:16569872<ref>PMID:16569872</ref>
-{{ABSTRACT_PUBMED_16569872}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 2f3k" style="background-color:#fffaf0;"></div>
-[[2f3k]] is a 2 chain structure of [[Virus protease]] with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3K OCA].
 ==See Also==
-*[[Virus protease|Virus protease]]
+*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:016569872</ref><references group="xtra"/>
+__TOC__
-[[Category: HIV-1 retropepsin]]
+</StructureSection>
 [[Category: Human immunodeficiency virus 1]]
-[[Category: Cammack, N.]]
+[[Category: Large Structures]]
-[[Category: Heilek-Snyder, G.]]
+[[Category: Cammack N]]
-[[Category: King, N M.]]
+[[Category: Heilek-Snyder G]]
-[[Category: Nalivaika, E A.]]
+[[Category: King NM]]
-[[Category: Prabu-Jeyabalan, M.]]
+[[Category: Nalivaika EA]]
-[[Category: Schiffer, C A.]]
+[[Category: Prabu-Jeyabalan M]]
-[[Category: Drug resistance]]
+[[Category: Schiffer CA]]
-[[Category: Hiv protease]]
-[[Category: Hydrolase]]
-[[Category: Ro1]]
-[[Category: Substrate envelope]]