2b1h: Difference between revisions

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-[[Image:2b1h.png|left|200px]]
-{{STRUCTURE_2b1h|  PDB=2b1h  |  SCENE=  }}
+==Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with UG29 peptide==
+<StructureSection load='2b1h' size='340' side='right'caption='[[2b1h]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2b1h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B1H FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b1h OCA], [https://pdbe.org/2b1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b1h RCSB], [https://www.ebi.ac.uk/pdbsum/2b1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b1h ProSAT]</span></td></tr>
+</table>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b1/2b1h_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b1h ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Human monoclonal antibody 2219 is a neutralizing antibody isolated from a human immunodeficiency virus type 1-infected individual. 2219 was originally selected for binding to a V3 fusion protein and can neutralize primary isolates from subtypes B, A, and F. Thus, 2219 represents a cross-reactive, human anti-V3 antibody. Fab 2219 binds to one face of the variable V3 beta-hairpin, primarily contacting conserved residues on the N-terminal beta-strand of V3, leaving the V3 crown or tip largely accessible. Three V3/2219 complexes reveal the antibody-bound conformations for both the N- and C-terminal regions that flank the V3 crown and illustrate how twisting of the V3 loop alters the relative dispositions and pairing of the amino acids in the adjacent V3 beta-strands and how the antibody can accommodate V3 loops with different sequences.
-===Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with UG29 peptide===
+Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity.,Stanfield RL, Gorny MK, Zolla-Pazner S, Wilson IA J Virol. 2006 Jun;80(12):6093-105. PMID:16731948<ref>PMID:16731948</ref>
-{{ABSTRACT_PUBMED_16731948}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 2b1h" style="background-color:#fffaf0;"></div>
-[[2b1h]] is a 3 chain structure of [[Antibody]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B1H OCA].
 ==See Also==
-*[[Antibody|Antibody]]
+*[[Antibody 3D structures|Antibody 3D structures]]
+*[[3D structures of human antibody|3D structures of human antibody]]
-==Reference==
+== References ==
-<ref group="xtra">PMID:016731948</ref><references group="xtra"/>
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Gorny, M K.]]
+[[Category: Large Structures]]
-[[Category: Stanfield, R L.]]
+[[Category: Gorny MK]]
-[[Category: Wilson, I A.]]
+[[Category: Stanfield RL]]
-[[Category: Zolla-Pazner, S.]]
+[[Category: Wilson IA]]
-[[Category: Fab-peptide complex]]
+[[Category: Zolla-Pazner S]]
-[[Category: Gp120]]
-[[Category: Hiv-1]]
-[[Category: Immune system]]
-[[Category: V3 loop]]