2ayg: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 ==Crystal structure of HPV6a E2 DNA binding domain bound to an 18 base pair DNA target==
-<StructureSection load='2ayg' size='340' side='right' caption='[[2ayg]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
+<StructureSection load='2ayg' size='340' side='right'caption='[[2ayg]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2ayg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpv6a Hpv6a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AYG FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2ayg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_6a Human papillomavirus type 6a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AYG FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1r8h|1r8h]], [[2ayb|2ayb]], [[2aye|2aye]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">E2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37122 HPV6A])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ayg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ayg OCA], [https://pdbe.org/2ayg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ayg RCSB], [https://www.ebi.ac.uk/pdbsum/2ayg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ayg ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ayg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ayg OCA], [http://pdbe.org/2ayg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ayg RCSB], [http://www.ebi.ac.uk/pdbsum/2ayg PDBsum]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/VE2_HPV6A VE2_HPV6A]] E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
+[https://www.uniprot.org/uniprot/VE2_HPV6A VE2_HPV6A] E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ay/2ayg_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ay/2ayg_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ayg ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 28: / Line 28: @@
 </div>
 <div class="pdbe-citations 2ayg" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Regulatory protein E2|Regulatory protein E2]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Hpv6a]]
+[[Category: Human papillomavirus type 6a]]
-[[Category: Brady, R L]]
+[[Category: Large Structures]]
-[[Category: Gaston, K]]
+[[Category: Brady RL]]
-[[Category: Hooley, E]]
+[[Category: Gaston K]]
-[[Category: Beta barrel]]
+[[Category: Hooley E]]
-[[Category: Double helix]]
-[[Category: Protein-dna complex]]
-[[Category: Transcription-dna complex]]