2ar6: Difference between revisions

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-{{Seed}}
-[[Image:2ar6.png|left|200px]]
-<!--
+==Pterocarpus angolensis Lectin (PAL) In Complex With The Pentasaccharide M592==
-The line below this paragraph, containing "STRUCTURE_2ar6", creates the "Structure Box" on the page.
+<StructureSection load='2ar6' size='340' side='right'caption='[[2ar6]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2ar6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AR6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AR6 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-{{STRUCTURE_2ar6|  PDB=2ar6  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ar6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ar6 OCA], [https://pdbe.org/2ar6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ar6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ar6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ar6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q8GSD2_PTEAG Q8GSD2_PTEAG]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ar/2ar6_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ar6 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The crystal structure of Pterocarpus angolensis lectin is determined in its ligand-free state, in complex with the fucosylated biantennary complex type decasaccharide NA2F, and in complex with a series of smaller oligosaccharide constituents of NA2F. These results together with thermodynamic binding data indicate that the complete oligosaccharide binding site of the lectin consists of five subsites allowing the specific recognition of the pentasaccharide GlcNAc beta(1-2)Man alpha(1-3)[GlcNAc beta(1-2)Man alpha(1-6)]Man. The mannose on the 1-6 arm occupies the monosaccharide binding site while the GlcNAc residue on this arm occupies a subsite that is almost identical to that of concanavalin A (con A). The core mannose and the GlcNAc beta(1-2)Man moiety on the 1-3 arm on the other hand occupy a series of subsites distinct from those of con A.
-===Pterocarpus angolensis Lectin (PAL) In Complex With The Pentasaccharide M592===
+Structural basis for the recognition of complex-type biantennary oligosaccharides by Pterocarpus angolensis lectin.,Buts L, Garcia-Pino A, Imberty A, Amiot N, Boons GJ, Beeckmans S, Versees W, Wyns L, Loris R FEBS J. 2006 Jun;273(11):2407-20. PMID:16704415<ref>PMID:16704415</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2ar6" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_16704415}}, adds the Publication Abstract to the page
+*[[Pal|Pal]]
-(as it appears on PubMed at http://www.pubmed.gov), where 16704415 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_16704415}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-AR6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AR6 OCA].
-==Reference==
-Structural basis for the recognition of complex-type biantennary oligosaccharides by Pterocarpus angolensis lectin., Buts L, Garcia-Pino A, Imberty A, Amiot N, Boons GJ, Beeckmans S, Versees W, Wyns L, Loris R, FEBS J. 2006 Jun;273(11):2407-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16704415 16704415]
 [[Category: Pterocarpus angolensis]]
-[[Category: Single protein]]
+[[Category: Amiot N]]
-[[Category: Amiot, N.]]
+[[Category: Beeckmans S]]
-[[Category: Beeckmans, S.]]
+[[Category: Boons GJ]]
-[[Category: Boons, G J.]]
+[[Category: Buts L]]
-[[Category: Buts, L.]]
+[[Category: Garcia-Pino A]]
-[[Category: Garcia-Pino, A.]]
+[[Category: Imberty A]]
-[[Category: Imberty, A.]]
+[[Category: Loris R]]
-[[Category: Loris, R.]]
+[[Category: Versees W]]
-[[Category: Versees, W.#.]]
+[[Category: Wyns L]]
-[[Category: Wyns, L.]]
-[[Category: Carbohydrate recognition]]
-[[Category: Lectin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:55:02 2008''