2ad1: Difference between revisions

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OCA

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 ==Human Sulfotransferase SULT1C2==
-<StructureSection load='2ad1' size='340' side='right' caption='[[2ad1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+<StructureSection load='2ad1' size='340' side='right'caption='[[2ad1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2ad1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AD1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AD1 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2ad1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AD1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AD1 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SULT1C2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ad1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ad1 OCA], [http://pdbe.org/2ad1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ad1 RCSB], [http://www.ebi.ac.uk/pdbsum/2ad1 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ad1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ad1 OCA], [https://pdbe.org/2ad1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ad1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ad1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ad1 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/ST1C2_HUMAN ST1C2_HUMAN]] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).
+[https://www.uniprot.org/uniprot/ST1C4_HUMAN ST1C4_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Can also sulfonate estrogenic compounds, however, the dietary flavonoids (phytoestrogen) and environmental estrogens, like bisphenol A are better substrates than 17beta-estradiol (E2) (PubMed:17425406, PubMed:28222028, PubMed:9852044, PubMed:26948952). Mediates the sulfation of doxorubicin and its analog epirubicin, two antitumor anthracyclines (PubMed:26948952).<ref>PMID:17425406</ref> <ref>PMID:26948952</ref> <ref>PMID:28222028</ref> <ref>PMID:9852044</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ad/2ad1_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ad/2ad1_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ad1 ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 29: / Line 30: @@
 ==See Also==
-*[[Sulfotransferase|Sulfotransferase]]
+*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H]]
+[[Category: Large Structures]]
-[[Category: Bochkarev, A]]
+[[Category: Arrowsmith CH]]
-[[Category: Dombrovski, L]]
+[[Category: Bochkarev A]]
-[[Category: Dong, A]]
+[[Category: Dombrovski L]]
-[[Category: Edwards, A M]]
+[[Category: Dong A]]
-[[Category: Loppnau, P]]
+[[Category: Edwards AM]]
-[[Category: Plotnikov, A N]]
+[[Category: Loppnau P]]
-[[Category: Structural genomic]]
+[[Category: Plotnikov AN]]
-[[Category: Sundstrom, M]]
+[[Category: Sundstrom M]]
-[[Category: Weigelt, J]]
+[[Category: Weigelt J]]
-[[Category: Sgc]]
-[[Category: Sulfate conjugation]]
-[[Category: Transferase]]
-[[Category: X-ray crystallography]]