2a4e: Difference between revisions

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==Crystal structure of mouse cadherin-11 EC1-2==
==Crystal structure of mouse cadherin-11 EC1-2==
<StructureSection load='2a4e' size='340' side='right' caption='[[2a4e]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='2a4e' size='340' side='right'caption='[[2a4e]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2a4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A4E FirstGlance]. <br>
<table><tr><td colspan='2'>[[2a4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A4E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zvn|1zvn]], [[1zxk|1zxk]], [[2a4c|2a4c]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cdh11, Cad-11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4e OCA], [https://pdbe.org/2a4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a4e RCSB], [https://www.ebi.ac.uk/pdbsum/2a4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a4e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4e OCA], [http://pdbe.org/2a4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a4e RCSB], [http://www.ebi.ac.uk/pdbsum/2a4e PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CAD11_MOUSE CAD11_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.  
[https://www.uniprot.org/uniprot/CAD11_MOUSE CAD11_MOUSE] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/2a4e_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/2a4e_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a4e ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
*[[Cadherin|Cadherin]]
*[[Cadherin 3D structures|Cadherin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Arkus, N]]
[[Category: Mus musculus]]
[[Category: Bahna, F]]
[[Category: Arkus N]]
[[Category: Chen, C P]]
[[Category: Bahna F]]
[[Category: Ciatto, C]]
[[Category: Chen CP]]
[[Category: Honig, B]]
[[Category: Ciatto C]]
[[Category: Jessell, T M]]
[[Category: Honig B]]
[[Category: Patel, S D]]
[[Category: Jessell TM]]
[[Category: Price, S R]]
[[Category: Patel SD]]
[[Category: Rajebhosale, M]]
[[Category: Price SR]]
[[Category: Shapiro, L]]
[[Category: Rajebhosale M]]
[[Category: Cadherin]]
[[Category: Shapiro L]]
[[Category: Calcium binding]]
[[Category: Cell adhesion]]
[[Category: Dimer]]

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