2a1y: Difference between revisions

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New page: left|200px<br /><applet load="2a1y" size="450" color="white" frame="true" align="right" spinBox="true" caption="2a1y, resolution 2.27Å" /> '''Crystal Structure of...
 
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[[Image:2a1y.gif|left|200px]]<br /><applet load="2a1y" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2a1y, resolution 2.27&Aring;" />
'''Crystal Structure of GuaC-GMP complex from Bacillus anthracis at 2.26 A Resolution.'''<br />


==About this Structure==
==Crystal Structure of GuaC-GMP complex from Bacillus anthracis at 2.26 A Resolution.==
2A1Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] with 5GP as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/GMP_reductase GMP reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.1.7 1.7.1.7] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2A1Y OCA].  
<StructureSection load='2a1y' size='340' side='right'caption='[[2a1y]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2a1y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A1Y FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a1y OCA], [https://pdbe.org/2a1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a1y RCSB], [https://www.ebi.ac.uk/pdbsum/2a1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a1y ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GUAC_BACAN GUAC_BACAN] Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/2a1y_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a1y ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
[[Category: GMP reductase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Blagova EV]]
[[Category: Blagova, E.V.]]
[[Category: Brannigan JA]]
[[Category: Brannigan, J.A.]]
[[Category: Fogg MJ]]
[[Category: Fogg, M.J.]]
[[Category: Grenha R]]
[[Category: Grenha, R.]]
[[Category: Levdikov VM]]
[[Category: Levdikov, V.M.]]
[[Category: Wilkinson AJ]]
[[Category: SPINE, Structural.Proteomics.in.Europe.]]
[[Category: Wilson KS]]
[[Category: Wilkinson, A.J.]]
[[Category: Wilson, K.S.]]
[[Category: 5GP]]
[[Category: and nucleotides: nucleotide and nucleoside interconversions]]
[[Category: gmp]]
[[Category: guac]]
[[Category: nucleosides]]
[[Category: purines]]
[[Category: pyrimidines]]
[[Category: spine]]
[[Category: structural genomics]]
[[Category: structural proteomics in europe]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 07:52:22 2007''

Latest revision as of 10:17, 23 August 2023

Crystal Structure of GuaC-GMP complex from Bacillus anthracis at 2.26 A Resolution.Crystal Structure of GuaC-GMP complex from Bacillus anthracis at 2.26 A Resolution.

Structural highlights

2a1y is a 1 chain structure with sequence from Bacillus anthracis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.27Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GUAC_BACAN Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2a1y, resolution 2.27Å

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