2a1y: Difference between revisions

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-[[Image:2a1y.gif|left|200px]]
- {{Structure
+==Crystal Structure of GuaC-GMP complex from Bacillus anthracis at 2.26 A Resolution.==
-|PDB= 2a1y |SIZE=350|CAPTION= <scene name='initialview01'>2a1y</scene>, resolution 2.27&Aring;
+<StructureSection load='2a1y' size='340' side='right'caption='[[2a1y]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=5GP:GUANOSINE-5&#39;-MONOPHOSPHATE'>5GP</scene>
+<table><tr><td colspan='2'>[[2a1y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A1Y FirstGlance]. <br>
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/GMP_reductase GMP reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.1.7 1.7.1.7] </span>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
-|GENE= guaC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a1y OCA], [https://pdbe.org/2a1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a1y RCSB], [https://www.ebi.ac.uk/pdbsum/2a1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a1y ProSAT]</span></td></tr>
-|RELATEDENTRY=[[1ypf|1YPF]]
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a1y OCA], [http://www.ebi.ac.uk/pdbsum/2a1y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a1y RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/GUAC_BACAN GUAC_BACAN] Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity).
+== Evolutionary Conservation ==
-'''Crystal Structure of GuaC-GMP complex from Bacillus anthracis at 2.26 A Resolution.'''
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
-==About this Structure==
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/2a1y_consurf.spt"</scriptWhenChecked>
-A1Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A1Y OCA].
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a1y ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
 [[Category: Bacillus anthracis]]
-[[Category: GMP reductase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Blagova EV]]
-[[Category: Blagova, E V.]]
+[[Category: Brannigan JA]]
-[[Category: Brannigan, J A.]]
+[[Category: Fogg MJ]]
-[[Category: Fogg, M J.]]
+[[Category: Grenha R]]
-[[Category: Grenha, R.]]
+[[Category: Levdikov VM]]
-[[Category: Levdikov, V M.]]
+[[Category: Wilkinson AJ]]
-[[Category: SPINE, Structural Proteomics in Europe.]]
+[[Category: Wilson KS]]
-[[Category: Wilkinson, A J.]]
-[[Category: Wilson, K S.]]
-[[Category: and nucleotides: nucleotide and nucleoside interconversion]]
-[[Category: gmp]]
-[[Category: guac]]
-[[Category: nucleoside]]
-[[Category: purine]]
-[[Category: pyrimidine]]
-[[Category: spine]]
-[[Category: structural genomic]]
-[[Category: structural proteomics in europe]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:46:45 2008''