2a18: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2a18.gif|left|200px]]<br /><applet load="2a18" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="2a18, resolution 2.28&Aring;" />
-'''carboxysome shell protein ccmK4, crystal form 2'''<br />
-==Overview==
+==carboxysome shell protein ccmK4, crystal form 2==
-Bacterial microcompartments are primitive organelles composed entirely of, protein subunits. Genomic sequence databases reveal the widespread, occurrence of microcompartments across diverse microbes. The prototypical, bacterial microcompartment is the carboxysome, a protein shell for, sequestering carbon fixation reactions. We report three-dimensional, crystal structures of multiple carboxysome shell proteins, revealing a, hexameric unit as the basic microcompartment building block and showing, how these hexamers assemble to form flat facets of the polyhedral shell., The structures suggest how molecular transport across the shell may be, controlled and how structural variations might govern the assembly and, architecture of these subcellular compartments.
+<StructureSection load='2a18' size='340' side='right'caption='[[2a18]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2a18]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechocystis_sp._PCC_6803 Synechocystis sp. PCC 6803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A18 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a18 OCA], [https://pdbe.org/2a18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a18 RCSB], [https://www.ebi.ac.uk/pdbsum/2a18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a18 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CCMK4_SYNY3 CCMK4_SYNY3] May be involved in the formation of the carboxysome, a polyhedral inclusion where RuBisCO is sequestered (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/2a18_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a18 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Bacterial microcompartments are primitive organelles composed entirely of protein subunits. Genomic sequence databases reveal the widespread occurrence of microcompartments across diverse microbes. The prototypical bacterial microcompartment is the carboxysome, a protein shell for sequestering carbon fixation reactions. We report three-dimensional crystal structures of multiple carboxysome shell proteins, revealing a hexameric unit as the basic microcompartment building block and showing how these hexamers assemble to form flat facets of the polyhedral shell. The structures suggest how molecular transport across the shell may be controlled and how structural variations might govern the assembly and architecture of these subcellular compartments.
-==About this Structure==
+Protein structures forming the shell of primitive bacterial organelles.,Kerfeld CA, Sawaya MR, Tanaka S, Nguyen CV, Phillips M, Beeby M, Yeates TO Science. 2005 Aug 5;309(5736):936-8. PMID:16081736<ref>PMID:16081736</ref>
-A18 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.] with NH4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2A18 OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-Protein structures forming the shell of primitive bacterial organelles., Kerfeld CA, Sawaya MR, Tanaka S, Nguyen CV, Phillips M, Beeby M, Yeates TO, Science. 2005 Aug 5;309(5736):936-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16081736 16081736]
+</div>
-[[Category: Single protein]]
+<div class="pdbe-citations 2a18" style="background-color:#fffaf0;"></div>
-[[Category: Synechocystis sp.]]
+== References ==
-[[Category: Beeby, M.]]
+<references/>
-[[Category: Kerfeld, C.A.]]
+__TOC__
-[[Category: Nguyen, C.V.]]
+</StructureSection>
-[[Category: Phillips, M.]]
+[[Category: Large Structures]]
-[[Category: Sawaya, M.R.]]
+[[Category: Synechocystis sp. PCC 6803]]
-[[Category: Tanaka, S.]]
+[[Category: Beeby M]]
-[[Category: Yeates, T.O.]]
+[[Category: Kerfeld CA]]
-[[Category: NH4]]
+[[Category: Nguyen CV]]
-[[Category: cyclic hexamer; c6 point symmetry]]
+[[Category: Phillips M]]
+[[Category: Sawaya MR]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 07:51:42 2007''
+[[Category: Tanaka S]]
+[[Category: Yeates TO]]