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==Crystal Structure of eIF2alpha Protein Kinase GCN2: Wild-Type in Apo Form.==
==Crystal Structure of eIF2alpha Protein Kinase GCN2: Wild-Type in Apo Form.==
<StructureSection load='1zyc' size='340' side='right' caption='[[1zyc]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='1zyc' size='340' side='right'caption='[[1zyc]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1zyc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZYC FirstGlance]. <br>
<table><tr><td colspan='2'>[[1zyc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZYC FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zyd|1zyd]], [[1zy4|1zy4]], [[1zy5|1zy5]], [[1zxe|1zxe]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GCN2, AAS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyc OCA], [https://pdbe.org/1zyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zyc RCSB], [https://www.ebi.ac.uk/pdbsum/1zyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zyc ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyc OCA], [http://pdbe.org/1zyc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zyc RCSB], [http://www.ebi.ac.uk/pdbsum/1zyc PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GCN2_YEAST GCN2_YEAST]] Stimulates GCN4 translation in amino acid-starved cells by phosphorylating the alpha subunit of eIF-2 (SUI2) on 'Ser-52'.  
[https://www.uniprot.org/uniprot/GCN2_YEAST GCN2_YEAST] Stimulates GCN4 translation in amino acid-starved cells by phosphorylating the alpha subunit of eIF-2 (SUI2) on 'Ser-52'.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zy/1zyc_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zy/1zyc_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Large Structures]]
[[Category: Transferase]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Burley, S K]]
[[Category: Burley SK]]
[[Category: Hinnebusch, A G]]
[[Category: Hinnebusch AG]]
[[Category: Padyana, A K]]
[[Category: Padyana AK]]
[[Category: Qiu, H]]
[[Category: Qiu H]]
[[Category: Roll-Mecak, A]]
[[Category: Roll-Mecak A]]
[[Category: Amino-acid starvation]]
[[Category: Eif2alpha kinase]]
[[Category: Protein kinase]]
[[Category: Signal transduction]]
[[Category: Starvation stress response]]
[[Category: Translation regulator]]

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