1zvx: Difference between revisions

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-{{Seed}}
-[[Image:1zvx.png|left|200px]]
-<!--
+==Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (R-enantiomer)==
-The line below this paragraph, containing "STRUCTURE_1zvx", creates the "Structure Box" on the page.
+<StructureSection load='1zvx' size='340' side='right'caption='[[1zvx]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1zvx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZVX FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FIN:(1R)-1-{[(4-METHOXY-1,1-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC+ACID'>FIN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_1zvx|  PDB=1zvx  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zvx OCA], [https://pdbe.org/1zvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zvx RCSB], [https://www.ebi.ac.uk/pdbsum/1zvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zvx ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MMP8_HUMAN MMP8_HUMAN] Can degrade fibrillar type I, II, and III collagens.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/1zvx_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zvx ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Potent and selective inhibitors of matrix metalloproteinases (MMPs), a family of zinc proteases that can degrade all the components of the extracellular matrix, could be useful for treatment of diseases such as cancer and arthritis. The most potent MMP inhibitors are based on hydroxamate as zinc-binding group (ZBG). alpha-Arylsulfonylamino phosphonates incorporate a particularly favorable combination of phosphonate as ZBG and arylsulfonylamino backbone so that their affinity exceptionally attains the nanomolar strength frequently observed for hydroxamate analogues. The detailed mode of binding of [1-(4'-methoxybiphenyl-4-sulfonylamino)-2-methylpropyl]phosphonate has been clarified by the crystal structures of the complexes that the R- and S-enantiomers respectively form with MMP-8. The reasons for the preferential MMP-8 inhibition by the R-phosphonate are underlined and the differences in the mode of binding of analogous alpha-arylsulfonylamino hydroxamates and carboxylates are discussed.
-===Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (R-enantiomer)===
+Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates.,Pochetti G, Gavuzzo E, Campestre C, Agamennone M, Tortorella P, Consalvi V, Gallina C, Hiller O, Tschesche H, Tucker PA, Mazza F J Med Chem. 2006 Feb 9;49(3):923-31. PMID:16451058<ref>PMID:16451058</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1zvx" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_16451058}}, adds the Publication Abstract to the page
+*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 16451058 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_16451058}}
+__TOC__
+</StructureSection>
-==About this Structure==
-ZVX is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVX OCA].
-==Reference==
-<ref group="xtra">PMID:16451058</ref><ref group="xtra">PMID:10422833</ref><ref group="xtra">PMID:10978185</ref><ref group="xtra">PMID:7737183</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Neutrophil collagenase]]
+[[Category: Large Structures]]
-[[Category: Agamennone, M.]]
+[[Category: Agamennone M]]
-[[Category: Campestre, C.]]
+[[Category: Campestre C]]
-[[Category: Consalvi, V.]]
+[[Category: Consalvi V]]
-[[Category: Gallina, C.]]
+[[Category: Gallina C]]
-[[Category: Gavuzzo, E.]]
+[[Category: Gavuzzo E]]
-[[Category: Hiller, O.]]
+[[Category: Hiller O]]
-[[Category: Mazza, F.]]
+[[Category: Mazza F]]
-[[Category: Pochetti, G.]]
+[[Category: Pochetti G]]
-[[Category: Tortorella, P.]]
+[[Category: Tortorella P]]
-[[Category: Tschesche, H.]]
+[[Category: Tschesche H]]
-[[Category: Tucker, P A.]]
+[[Category: Tucker PA]]
-[[Category: Hydrolase]]
-[[Category: Phosphonic inhibitor]]
-[[Category: Stereoselective inhibition]]
-[[Category: Sulfonamide junction]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:30:01 2009''