1yyq: Difference between revisions

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<StructureSection load='1yyq' size='340' side='right'caption='[[1yyq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='1yyq' size='340' side='right'caption='[[1yyq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1yyq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fussp Fussp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YYQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[1yyq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_sporotrichioides Fusarium sporotrichioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YYQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jfa|1jfa]], [[1jfg|1jfg]], [[1kiy|1kiy]], [[1kiz|1kiz]], [[1yyr|1yyr]], [[1yys|1yys]], [[1yyt|1yyt]], [[1yyu|1yyu]], [[1yj4|1yj4]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRI5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5514 FUSSP])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trichodiene_synthase Trichodiene synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.6 4.2.3.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yyq OCA], [https://pdbe.org/1yyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yyq RCSB], [https://www.ebi.ac.uk/pdbsum/1yyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yyq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yyq OCA], [https://pdbe.org/1yyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yyq RCSB], [https://www.ebi.ac.uk/pdbsum/1yyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yyq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TRI5_FUSSP TRI5_FUSSP]] TS is a member of the terpene cyclase group of enzymes. It catalyzes the isomerization and cyclization of farnesyl pyro-phosphate to form trichodiene, the first cyclic intermediate in the biosynthetic pathway for trichothecenes. It serves to branch trichothecene biosynthesis from the isoprenoid pathway.  
[https://www.uniprot.org/uniprot/TRI5_FUSSP TRI5_FUSSP] TS is a member of the terpene cyclase group of enzymes. It catalyzes the isomerization and cyclization of farnesyl pyro-phosphate to form trichodiene, the first cyclic intermediate in the biosynthetic pathway for trichothecenes. It serves to branch trichothecene biosynthesis from the isoprenoid pathway.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Fussp]]
[[Category: Fusarium sporotrichioides]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Trichodiene synthase]]
[[Category: Cane DE]]
[[Category: Cane, D E]]
[[Category: Christianson DW]]
[[Category: Christianson, D W]]
[[Category: Coates RM]]
[[Category: Coates, R M]]
[[Category: Pyun HJ]]
[[Category: Pyun, H J]]
[[Category: Rynkiewicz MJ]]
[[Category: Rynkiewicz, M J]]
[[Category: Vedula LS]]
[[Category: Vedula, L S]]
[[Category: Lyase]]
[[Category: Pyrophosphate]]
[[Category: Site-directed mutant]]
[[Category: Terpenoid cyclase fold]]

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