1y8h: Difference between revisions

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-[[Image:1y8h.png|left|200px]]
-{{STRUCTURE_1y8h|  PDB=1y8h  |  SCENE=  }}
+==HORSE METHEMOGLOBIN LOW SALT, PH 7.0==
+<StructureSection load='1y8h' size='340' side='right'caption='[[1y8h]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1y8h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y8H FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y8h OCA], [https://pdbe.org/1y8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y8h RCSB], [https://www.ebi.ac.uk/pdbsum/1y8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y8h ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HBA_HORSE HBA_HORSE] Involved in oxygen transport from the lung to the various peripheral tissues.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y8/1y8h_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y8h ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+A new relaxed state has been characterized in the crystals of horse methemoglobin grown at neutral pH at low ionic concentration and their low humidity variants. The crystals provide an example for improvement in X-ray diffraction quality with reduced solvent content. Only the classical R state has been so far observed in liganded horse hemoglobin. The state characterized in the present study lies in between the R state and the R2 state characterized earlier in liganded human hemoglobin. The results presented here, along with those of earlier studies, suggest that relaxed and tense hemoglobin can access ensembles of states.
-===HORSE METHEMOGLOBIN LOW SALT, PH 7.0===
+A new relaxed state in horse methemoglobin characterized by crystallographic studies.,Sankaranarayanan R, Biswal BK, Vijayan M Proteins. 2005 Aug 15;60(3):547-51. PMID:15887226<ref>PMID:15887226</ref>
-{{ABSTRACT_PUBMED_15887226}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 1y8h" style="background-color:#fffaf0;"></div>
-[[1y8h]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y8H OCA].
 ==See Also==
-*[[Hemoglobin|Hemoglobin]]
+*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:015887226</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Equus caballus]]
-[[Category: Biswal, B K.]]
+[[Category: Large Structures]]
-[[Category: Sankaranarayanan, R.]]
+[[Category: Biswal BK]]
-[[Category: Vijayan, M.]]
+[[Category: Sankaranarayanan R]]
-[[Category: Allosteric transition]]
+[[Category: Vijayan M]]
-[[Category: Aquo methemoglobin]]
-[[Category: Oxygen storage-transport complex]]
-[[Category: Quarternary association]]