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[[Image:1xe3.jpg|left|200px]]
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{{STRUCTURE_1xe3|  PDB=1xe3  |  SCENE=  }}
'''Crystal Structure of purine nucleoside phosphorylase DeoD from Bacillus anthracis'''


==Crystal Structure of purine nucleoside phosphorylase DeoD from Bacillus anthracis==
<StructureSection load='1xe3' size='340' side='right'caption='[[1xe3]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1xe3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XE3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xe3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xe3 OCA], [https://pdbe.org/1xe3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xe3 RCSB], [https://www.ebi.ac.uk/pdbsum/1xe3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xe3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DEOD_BACAN DEOD_BACAN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/1xe3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xe3 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since these are recognized as potential targets in antibacterial therapy. Purine nucleoside phosphorylase is a key enzyme in the purine-salvage pathway. The crystal structure of purine nucleoside phosphorylase (DeoD) from B. anthracis has been solved by molecular replacement at 2.24 A resolution and refined to an R factor of 18.4%. This is the first report of a DeoD structure from a Gram-positive bacterium.


==Overview==
Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis.,Grenha R, Levdikov VM, Fogg MJ, Blagova EV, Brannigan JA, Wilkinson AJ, Wilson KS Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 May 1;61(Pt, 5):459-62. Epub 2005 Apr 9. PMID:16511068<ref>PMID:16511068</ref>
Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since these are recognized as potential targets in antibacterial therapy. Purine nucleoside phosphorylase is a key enzyme in the purine-salvage pathway. The crystal structure of purine nucleoside phosphorylase (DeoD) from B. anthracis has been solved by molecular replacement at 2.24 A resolution and refined to an R factor of 18.4%. This is the first report of a DeoD structure from a Gram-positive bacterium.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1XE3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XE3 OCA].
</div>
<div class="pdbe-citations 1xe3" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis., Grenha R, Levdikov VM, Fogg MJ, Blagova EV, Brannigan JA, Wilkinson AJ, Wilson KS, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 May 1;61(Pt, 5):459-62. Epub 2005 Apr 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16511068 16511068]
*[[Purine nucleoside phosphorylase 3D structures|Purine nucleoside phosphorylase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
[[Category: Purine-nucleoside phosphorylase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Blagova EV]]
[[Category: Blagova, E V.]]
[[Category: Brannigan JA]]
[[Category: Brannigan, J A.]]
[[Category: Fogg M]]
[[Category: Fogg, M.]]
[[Category: Grenha R]]
[[Category: Grenha, R.]]
[[Category: Levdikov VM]]
[[Category: Levdikov, V M.]]
[[Category: Wilkinson AJ]]
[[Category: SPINE, Structural Proteomics in Europe.]]
[[Category: Wilson KS]]
[[Category: Wilkinson, A J.]]
[[Category: Wilson, K S.]]
[[Category: Deod]]
[[Category: Purine nucleoside phosphorylase]]
[[Category: Spine]]
[[Category: Structural genomic]]
[[Category: Structural proteomics in europe]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:14:13 2008''

Latest revision as of 09:44, 23 August 2023

Crystal Structure of purine nucleoside phosphorylase DeoD from Bacillus anthracisCrystal Structure of purine nucleoside phosphorylase DeoD from Bacillus anthracis

Structural highlights

1xe3 is a 6 chain structure with sequence from Bacillus anthracis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.24Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DEOD_BACAN

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since these are recognized as potential targets in antibacterial therapy. Purine nucleoside phosphorylase is a key enzyme in the purine-salvage pathway. The crystal structure of purine nucleoside phosphorylase (DeoD) from B. anthracis has been solved by molecular replacement at 2.24 A resolution and refined to an R factor of 18.4%. This is the first report of a DeoD structure from a Gram-positive bacterium.

Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis.,Grenha R, Levdikov VM, Fogg MJ, Blagova EV, Brannigan JA, Wilkinson AJ, Wilson KS Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 May 1;61(Pt, 5):459-62. Epub 2005 Apr 9. PMID:16511068[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. Grenha R, Levdikov VM, Fogg MJ, Blagova EV, Brannigan JA, Wilkinson AJ, Wilson KS. Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 May 1;61(Pt, 5):459-62. Epub 2005 Apr 9. PMID:16511068 doi:10.1107/S174430910501095X

1xe3, resolution 2.24Å

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