1u5d: Difference between revisions

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<StructureSection load='1u5d' size='340' side='right'caption='[[1u5d]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='1u5d' size='340' side='right'caption='[[1u5d]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1u5d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5D FirstGlance]. <br>
<table><tr><td colspan='2'>[[1u5d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1u5g|1u5g]], [[1u5e|1u5e]], [[1u5f|1u5f]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSSKAP55 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5d OCA], [https://pdbe.org/1u5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5d RCSB], [https://www.ebi.ac.uk/pdbsum/1u5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5d OCA], [https://pdbe.org/1u5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5d RCSB], [https://www.ebi.ac.uk/pdbsum/1u5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/SKAP1_HUMAN SKAP1_HUMAN]] Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.<ref>PMID:10856234</ref> <ref>PMID:11909961</ref> <ref>PMID:12652296</ref> <ref>PMID:15939789</ref> <ref>PMID:16980616</ref>
[https://www.uniprot.org/uniprot/SKAP1_HUMAN SKAP1_HUMAN] Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.<ref>PMID:10856234</ref> <ref>PMID:11909961</ref> <ref>PMID:12652296</ref> <ref>PMID:15939789</ref> <ref>PMID:16980616</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Eck, M J]]
[[Category: Eck MJ]]
[[Category: Neel, B G]]
[[Category: Neel BG]]
[[Category: Swanson, K D]]
[[Category: Swanson KD]]
[[Category: Tang, Y]]
[[Category: Tang Y]]
[[Category: Ph domain]]
[[Category: Signaling protein]]

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