1tw7: Difference between revisions

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-[[Image:1tw7.png|left|200px]]
-{{STRUCTURE_1tw7|  PDB=1tw7  |  SCENE=  }}
+==Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target==
+<StructureSection load='1tw7' size='340' side='right'caption='[[1tw7]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1tw7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TW7 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tw7 OCA], [https://pdbe.org/1tw7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tw7 RCSB], [https://www.ebi.ac.uk/pdbsum/1tw7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tw7 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q5RTL1_9HIV1 Q5RTL1_9HIV1]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tw/1tw7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tw7 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+This report examines structural changes in a highly mutated, clinical multidrug-resistant HIV-1 protease, and the crystal structure has been solved to 1.3 A resolution in the absence of any inhibitor. This protease variant contains codon mutations at positions 10, 36, 46, 54, 62, 63, 71, 82, 84, and 90 that confer resistance to protease inhibitors. Major differences between the wild-type and the variant include a structural change initiated by the M36V mutation and amplified by additional mutations in the flaps of the protease, resulting in a "wide-open" structure that represents an opening that is 8 A wider than the "open" structure of the wild-type protease. A second structural change is triggered by the L90M mutation that results in reshaping the 23-32 segment. A third key structural change of the protease is due to the mutations from longer to shorter amino acid side chains at positions 82 and 84.
-===Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target===
+"Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target.,Martin P, Vickrey JF, Proteasa G, Jimenez YL, Wawrzak Z, Winters MA, Merigan TC, Kovari LC Structure. 2005 Dec;13(12):1887-95. PMID:16338417<ref>PMID:16338417</ref>
-{{ABSTRACT_PUBMED_16338417}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 1tw7" style="background-color:#fffaf0;"></div>
-[[1tw7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TW7 OCA].
 ==See Also==
-*[[Virus protease|Virus protease]]
+*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:016338417</ref><references group="xtra"/>
+__TOC__
-[[Category: HIV-1 retropepsin]]
+</StructureSection>
 [[Category: Human immunodeficiency virus 1]]
-[[Category: Jimenez, Y L.]]
+[[Category: Large Structures]]
-[[Category: Kovari, L C.]]
+[[Category: Jimenez YL]]
-[[Category: Martin, P.]]
+[[Category: Kovari LC]]
-[[Category: Merigan, T C.]]
+[[Category: Martin P]]
-[[Category: Proteasa, G.]]
+[[Category: Merigan TC]]
-[[Category: Vickrey, J F.]]
+[[Category: Proteasa G]]
-[[Category: Wawrzak, Z.]]
+[[Category: Vickrey JF]]
-[[Category: Winters, M A.]]
+[[Category: Wawrzak Z]]
-[[Category: Aid]]
+[[Category: Winters MA]]
-[[Category: Aspartyl protease]]
-[[Category: Hiv protease]]
-[[Category: Hydrolase]]
-[[Category: Multi-drug resistance]]
-[[Category: Polyprotein]]