1t2a: Difference between revisions

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[[Image:1t2a.gif|left|200px]]


{{Structure
==Crystal structure of human GDP-D-mannose 4,6-dehydratase==
|PDB= 1t2a |SIZE=350|CAPTION= <scene name='initialview01'>1t2a</scene>, resolution 1.84&Aring;
<StructureSection load='1t2a' size='340' side='right'caption='[[1t2a]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> and <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>
<table><tr><td colspan='2'>[[1t2a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T2A FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/GDP-mannose_4,6-dehydratase GDP-mannose 4,6-dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.47 4.2.1.47]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
|GENE= GMDS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2a OCA], [https://pdbe.org/1t2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t2a RCSB], [https://www.ebi.ac.uk/pdbsum/1t2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t2a ProSAT]</span></td></tr>
 
</table>
'''Crystal structure of human GDP-D-mannose 4,6-dehydratase'''
== Function ==
 
[https://www.uniprot.org/uniprot/GMDS_HUMAN GMDS_HUMAN] Conversion of GDP-D-mannose to GDP-4-keto-6-D-deoxymannose.
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
1T2A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2A OCA].  
Check<jmol>
[[Category: GDP-mannose 4,6-dehydratase]]
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t2/1t2a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t2a ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Houston, S.]]
[[Category: Houston S]]
[[Category: Loppnau, P.]]
[[Category: Loppnau P]]
[[Category: Oppermann, U.]]
[[Category: Oppermann U]]
[[Category: Sharma, S.]]
[[Category: Sharma S]]
[[Category: Sundstrom, M.]]
[[Category: Sundstrom M]]
[[Category: Vedadi, M.]]
[[Category: Vedadi M]]
[[Category: Walker, J R.]]
[[Category: Walker JR]]
[[Category: Wasney, G.]]
[[Category: Wasney G]]
[[Category: GDP]]
[[Category: NDP]]
[[Category: rossman-fold]]
[[Category: sdr]]
[[Category: short-chain dehydrogenase/reductase]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 13:40:59 2008''

Latest revision as of 09:23, 23 August 2023

Crystal structure of human GDP-D-mannose 4,6-dehydrataseCrystal structure of human GDP-D-mannose 4,6-dehydratase

Structural highlights

1t2a is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.84Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GMDS_HUMAN Conversion of GDP-D-mannose to GDP-4-keto-6-D-deoxymannose.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1t2a, resolution 1.84Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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