1suj: Difference between revisions

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-{{Seed}}
-[[Image:1suj.png|left|200px]]
-<!--
+==X-ray crystal structure of ambystoma tigrinum cone arrestin==
-The line below this paragraph, containing "STRUCTURE_1suj", creates the "Structure Box" on the page.
+<StructureSection load='1suj' size='340' side='right'caption='[[1suj]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1suj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ambystoma_tigrinum Ambystoma tigrinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SUJ FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1suj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1suj OCA], [https://pdbe.org/1suj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1suj RCSB], [https://www.ebi.ac.uk/pdbsum/1suj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1suj ProSAT]</span></td></tr>
-{{STRUCTURE_1suj|  PDB=1suj  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q9PTE7_AMBTI Q9PTE7_AMBTI]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/su/1suj_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1suj ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Arrestins play a fundamental role in the regulation and signal transduction of G protein-coupled receptors. Here we describe the crystal structure of cone arrestin at 2.3A resolution. The overall structure of cone visual arrestin is similar to the crystal structures of rod visual and the non-visual arrestin-2, consisting of two domains, each containing ten beta-sheets. However, at the tertiary structure level, there are two major differences, in particular on the concave surfaces of the two domains implicated in receptor binding and in the loop between beta-strands I and II. Functional analysis shows that cone arrestin, in sharp contrast to its rod counterpart, bound cone pigments and non-visual receptors. Conversely, non-visual arrestin-2 bound cone pigments, suggesting that it may also regulate phototransduction and/or photopigment trafficking in cone photoreceptors. These findings indicate that cone arrestin displays structural and functional features intermediate between the specialized rod arrestin and the non-visual arrestins, which have broad receptor specificity. A unique functional feature of cone arrestin was the low affinity for its cognate receptor, resulting in an unusually rapid dissociation of the complex. Transient arrestin binding to the photopigment in cones may be responsible for the extremely rapid regeneration and reuse of the photopigment that is essential for cone function at high levels of illumination.
-===X-ray crystal structure of ambystoma tigrinum cone arrestin===
+Crystal structure of cone arrestin at 2.3A: evolution of receptor specificity.,Sutton RB, Vishnivetskiy SA, Robert J, Hanson SM, Raman D, Knox BE, Kono M, Navarro J, Gurevich VV J Mol Biol. 2005 Dec 16;354(5):1069-80. Epub 2005 Nov 2. PMID:16289201<ref>PMID:16289201</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1suj" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_16289201}}, adds the Publication Abstract to the page
+*[[Arrestin 3D structures|Arrestin 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 16289201 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_16289201}}
+__TOC__
+</StructureSection>
-==About this Structure==
-SUJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ambystoma_tigrinum Ambystoma tigrinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUJ OCA].
-==Reference==
-Crystal structure of cone arrestin at 2.3A: evolution of receptor specificity., Sutton RB, Vishnivetskiy SA, Robert J, Hanson SM, Raman D, Knox BE, Kono M, Navarro J, Gurevich VV, J Mol Biol. 2005 Dec 16;354(5):1069-80. Epub 2005 Nov 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16289201 16289201]
 [[Category: Ambystoma tigrinum]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
+[[Category: Navarro J]]
-[[Category: Sensory transduction]]
+[[Category: Sutton RB]]
-[[Category: Signaling protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan  7 20:07:53 2009''