1qxk: Difference between revisions

<StructureSection load='1qxk' size='340' side='right'caption='[[1qxk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>

== Structural highlights ==

<table><tr><td colspan='2'>[[1qxk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QXK FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=429:2-{4-[2-ACETYLAMINO-3-(4-CARBOXYMETHOXY-3-HYDROXY-PHENYL)-PROPIONYLAMINO]-BUTOXY}-6-HYDROXY-BENZOIC+ACID+METHYL+ESTER'>429</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qxk OCA], [https://pdbe.org/1qxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qxk RCSB], [https://www.ebi.ac.uk/pdbsum/1qxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qxk ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qx/1qxk_consurf.spt"</scriptWhenChecked>

    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>

    <text>to colour the structure by Evolutionary Conservation</text>

  </jmolCheckbox>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qxk ConSurf].

<div style="clear:both"></div>

<div style="background-color:#fffaf0;">

Identification of a monoacid-based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B.,Xin Z, Liu G, Abad-Zapatero C, Pei Z, Szczepankiewicz BG, Li X, Zhang T, Hutchins CW, Hajduk PJ, Ballaron SJ, Stashko MA, Lubben TH, Trevillyan JM, Jirousek MR Bioorg Med Chem Lett. 2003 Nov 17;13(22):3947-50. PMID:14592481<ref>PMID:14592481</ref>

==See Also==

*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]

== References ==

<references/>

</StructureSection>

[[Category: Large Structures]]

[[Category: Abad-Zapatero C]]

[[Category: Ballaron SJ]]

[[Category: Hajduk PJ]]

[[Category: Hutchins CW]]

[[Category: Jirousek MR]]

[[Category: Li X]]

[[Category: Liu G]]

[[Category: Lubben TH]]

[[Category: Pei Z]]

[[Category: Stashko MA]]

[[Category: Szczepankiewick BG]]

[[Category: Trevillyan JM]]

[[Category: Xin Z]]

[[Category: Zhang T]]