P73: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (11 intermediate revisions by 3 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load=' | <StructureSection load='' size='350' side='right' caption='Human p73 DNA-binding domain complex with Tris, glycerol and Zn+2 ion (grey), [[2xwc]]' scene='46/468230/Cv/2' pspeed='8'> | ||
'''p73''' is a protein related to p53 tumor suppressor. It is involved in cell cycle regulation and induction of apoptosis<ref>PMID:9891077</ref>. p73 has several variants differing in their C- or N-terminal. p73 contains DNA-binding domain (DBD residues 112-312); tetramerization domain (TD residues 351-398). | '''p73''' is a protein related to p53 tumor suppressor. It is involved in cell cycle regulation and induction of apoptosis<ref>PMID:9891077</ref>. p73 has several variants differing in their C- or N-terminal. p73 contains DNA-binding domain (DBD residues 112-312); tetramerization domain (TD residues 351-398). | ||
== Structural highlights == | == Structural highlights == | ||
*<scene name='46/468230/Cv/5'>1st Zn coordination site</scene>. | |||
*<scene name='46/468230/Cv/6'>2nd Zn coordination site</scene>. | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of p73 == | == 3D Structures of p73 == | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
Domains - DNA-binding (DBD) 112-311; Tetramerization (TD) 351-398; C-terminal 439-506. | |||
[[1cok]] – hp73 C terminal – human – NMR | [[1cok]] – hp73 C terminal – human – NMR | ||
| Line 13: | Line 17: | ||
[[2kby]] – hp73 TD – NMR | [[2kby]] – hp73 TD – NMR | ||
[[2wqi]], [[2wqj]], [[2wtt]] - hp73 TD | [[2wqi]], [[2wqj]], [[2wtt]] - hp73 TD<br /> | ||
[[5hob]], [[5hoc]] - hp73 TD (mutant) <br /> | |||
[[2xwc]] – hp73 DBD (mutant)<br /> | [[2xwc]] – hp73 DBD (mutant)<br /> | ||
[[3vd0]], [[3vd1]], [[3vd2]], [[4g82]], [[4g83]], [[4guo]], [[4guq]] – hp73 DBD + DNA<br /> | [[2nb1]] - hp73 TD (mutant) + hp63 TD (mutant)<br /> | ||
[[3vd0]], [[3vd1]], [[3vd2]], [[4g82]], [[4g83]], [[4guo]], [[4guq]], [[5kbd]], [[7ezj]] – hp73 DBD + DNA<br /> | |||
[[4a63]] – hp73 DBD + apoptosis stimulating of p53 protein<br /> | [[4a63]] – hp73 DBD + apoptosis stimulating of p53 protein<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||