P73: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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-{{STRUCTURE_2xwc|  PDB=2xwc  | SIZE=400| SCENE= |right|CAPTION=Monomer of the dimeric human p73 DNA-binding domain complex with Tris, glycerol and Zn+2 ion (grey), [[2xwc]] }}
+<StructureSection load='' size='350' side='right' caption='Human p73 DNA-binding domain complex with Tris, glycerol and Zn+2 ion (grey), [[2xwc]]' scene='46/468230/Cv/2' pspeed='8'>
-'''p73''' is a protein related to p53 tumor suppressor.  It is involved in cell cycle regulation and induction of apoptosis.  P73 has several variants differing in their C- or N-terminal.  P73 contains DNA-binding domain (DBD residues 112-312); tetramerization domain (TD residues 351-398).
- {{TOC limit|limit=2}}
+'''p73''' is a protein related to p53 tumor suppressor.  It is involved in cell cycle regulation and induction of apoptosis<ref>PMID:9891077</ref>.  p73 has several variants differing in their C- or N-terminal.  p73 contains DNA-binding domain (DBD residues 112-312); tetramerization domain (TD residues 351-398).
+== Structural highlights ==
+*<scene name='46/468230/Cv/5'>1st Zn coordination site</scene>.
+*<scene name='46/468230/Cv/6'>2nd Zn coordination site</scene>.
+</StructureSection>
 == 3D Structures of p73 ==
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+Domains - DNA-binding (DBD) 112-311; Tetramerization (TD) 351-398; C-terminal 439-506.
 [[1cok]] – hp73 C terminal – human – NMR
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 [[2kby]] – hp73 TD – NMR
-[[2wqi]], [[2wqj]], [[2wtt]] - hp73 TD
+[[2wqi]], [[2wqj]], [[2wtt]] - hp73 TD<br />
+[[5hob]], [[5hoc]] - hp73 TD (mutant) <br />
 [[2xwc]] – hp73 DBD (mutant)<br />
-[[3vd0]], [[3dv1]], [[3dv2]], [[4g82]], [[4g83]], [[4guo]], [[4guq]] – hp73 DBD + DNA<br />
+[[2nb1]] - hp73 TD (mutant) + hp63 TD (mutant)<br />
+[[3vd0]], [[3vd1]], [[3vd2]], [[4g82]], [[4g83]], [[4guo]], [[4guq]], [[5kbd]], [[7ezj]] – hp73 DBD + DNA<br />
 [[4a63]] – hp73 DBD + apoptosis stimulating of p53 protein<br />
+== References ==
+<references/>
 [[Category:Topic Page]]