5hob: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
m Protected "5hob" [edit=sysop:move=sysop]
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 5hob is ON HOLD  until Paper Publication
==p73 homo-tetramerization domain mutant I==
<StructureSection load='5hob' size='340' side='right'caption='[[5hob]], [[Resolution|resolution]] 1.22&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5hob]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HOB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.220013&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hob OCA], [https://pdbe.org/5hob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hob RCSB], [https://www.ebi.ac.uk/pdbsum/5hob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hob ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>


Authors: Coutandin, D., Krojer, T., Salah, E., Mathea, S., Knapp, S., Dotsch, V.
==See Also==
 
*[[P73|P73]]
Description:  
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Knapp, S]]
__TOC__
[[Category: Krojer, T]]
</StructureSection>
[[Category: Mathea, S]]
[[Category: Homo sapiens]]
[[Category: Coutandin, D]]
[[Category: Large Structures]]
[[Category: Dotsch, V]]
[[Category: Coutandin D]]
[[Category: Salah, E]]
[[Category: Dotsch V]]
[[Category: Knapp S]]
[[Category: Krojer T]]
[[Category: Mathea S]]
[[Category: Salah E]]

Latest revision as of 13:48, 16 August 2023

p73 homo-tetramerization domain mutant Ip73 homo-tetramerization domain mutant I

Structural highlights

5hob is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.220013Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

P73_HUMAN Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.[1] [2] [3]

See Also

References

  1. ↑ Grob TJ, Novak U, Maisse C, Barcaroli D, Luthi AU, Pirnia F, Hugli B, Graber HU, De Laurenzi V, Fey MF, Melino G, Tobler A. Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ. 2001 Dec;8(12):1213-23. PMID:11753569 doi:10.1038/sj.cdd.4400962
  2. ↑ Kaelin WG Jr. The emerging p53 gene family. J Natl Cancer Inst. 1999 Apr 7;91(7):594-8. PMID:10203277
  3. ↑ Koida N, Ozaki T, Yamamoto H, Ono S, Koda T, Ando K, Okoshi R, Kamijo T, Omura K, Nakagawara A. Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation. J Biol Chem. 2008 Mar 28;283(13):8555-63. doi: 10.1074/jbc.M710608200. Epub 2008 , Jan 3. PMID:18174154 doi:10.1074/jbc.M710608200

5hob, resolution 1.22Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=5hob&oldid=3834486"