3kd0: Difference between revisions

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-[[Image:3kd0.png|left|200px]]
-{{STRUCTURE_3kd0|  PDB=3kd0  |  SCENE=  }}
+==Human thioredoxin C35S,C62S,C69S,C73S mutant showing cadmium chloride bound to the active site==
+<StructureSection load='3kd0' size='340' side='right'caption='[[3kd0]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-===Human thioredoxin C35S,C62S,C69S,C73S mutant showing cadmium chloride bound to the active site===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3kd0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KD0 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-[[3kd0]] is a 1 chain structure of [[Thioredoxin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KD0 OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kd0 OCA], [https://pdbe.org/3kd0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kd0 RCSB], [https://www.ebi.ac.uk/pdbsum/3kd0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kd0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/THIO_HUMAN THIO_HUMAN] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref>   ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref>
 ==See Also==
-*[[Thioredoxin|Thioredoxin]]
+*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Emsley, J.]]
+[[Category: Large Structures]]
-[[Category: Hall, G.]]
+[[Category: Emsley J]]
-[[Category: Disulfide bond]]
+[[Category: Hall G]]
-[[Category: Electron transport]]
-[[Category: Oxidoreductase]]
-[[Category: Redox-active center]]
-[[Category: Thioredoxin fold]]
-[[Category: Transport]]