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==Crystal Structure of B/Perth Neuraminidase D197E mutant in complex with Oseltamivir==
==Crystal Structure of B/Perth Neuraminidase D197E mutant in complex with Oseltamivir==
<StructureSection load='3k3a' size='340' side='right' caption='[[3k3a]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
<StructureSection load='3k3a' size='340' side='right'caption='[[3k3a]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3k3a]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K3A FirstGlance]. <br>
<table><tr><td colspan='2'>[[3k3a]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Perth/211/2001) Influenza B virus (B/Perth/211/2001)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K3A FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3k36|3k36]], [[3k37|3k37]], [[3k38|3k38]], [[3k39|3k39]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k3a OCA], [https://pdbe.org/3k3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k3a RCSB], [https://www.ebi.ac.uk/pdbsum/3k3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k3a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k3a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k3a RCSB], [http://www.ebi.ac.uk/pdbsum/3k3a PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q3S340_9INFB Q3S340_9INFB]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3k3a" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Neuraminidase|Neuraminidase]]
*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Exo-alpha-sialidase]]
[[Category: Large Structures]]
[[Category: Influenza b virus]]
[[Category: McKimm-Breschkin JL]]
[[Category: McKimm-Breschkin, J L]]
[[Category: Oakley AJ]]
[[Category: Oakley, A J]]
[[Category: 196618-13-0]]
[[Category: Cell membrane]]
[[Category: Glycosidase]]
[[Category: Gs-4071]]
[[Category: Hydrolase]]
[[Category: Influenza]]
[[Category: Membrane]]
[[Category: Mutation]]
[[Category: Neuraminidase]]
[[Category: Oseltamivir]]
[[Category: Resistance]]
[[Category: Tamiflu]]
[[Category: Transmembrane]]
[[Category: Virion]]

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