3df6: Difference between revisions

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[[Image:3df6.png|left|200px]]


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==The thermo- and acido-stable ORF-99 from the archaeal virus AFV1==
The line below this paragraph, containing "STRUCTURE_3df6", creates the "Structure Box" on the page.
<StructureSection load='3df6' size='340' side='right'caption='[[3df6]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3df6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Acidianus_filamentous_virus_1 Acidianus filamentous virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DF6 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
{{STRUCTURE_3df6|  PDB=3df6  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3df6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3df6 OCA], [https://pdbe.org/3df6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3df6 RCSB], [https://www.ebi.ac.uk/pdbsum/3df6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3df6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Y099_AFV1Y Y099_AFV1Y]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Acidianus Filamentous Virus 1 (AFV1), isolated from acidic hot springs, is an enveloped lipid-containing archaeal filamentous virus with a linear double-stranded DNA genome. It infects Acidianus, which is a hyperthermostable archaea growing at 85 degrees C and acidic pHs, below pH 3. AFV1-99, a protein of 99 amino acids of unknown function, has homologues in the archaeal virus families Lipothrixviridae and Rudiviridae. We determined the crystal structure of AFV1-99 at 2.05 A resolution. AFV1-99 has a new fold, is hyperthermostable (up to 95 degrees C) and resists to extreme pH (between pH 0 and 11) and to the combination of high temperature (95 degrees C) and low pH (pH 0). It possesses characteristics of hyperthermostable proteins, such as a high content of charged residues.


===ORF99 from the Archaeal Virus AFV1 is a Natural Mimic of the Ab-initio Designed Protein Top7===
The thermo- and acido-stable ORF-99 from the archaeal virus AFV1.,Goulet A, Spinelli S, Blangy S, van Tilbeurgh H, Leulliot N, Basta T, Prangishvili D, Cambillau C, Campanacci V Protein Sci. 2009 Jun;18(6):1316-20. PMID:19472363<ref>PMID:19472363</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3df6" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 19472363 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_19472363}}
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</StructureSection>
==About this Structure==
3DF6 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Acidianus_filamentous_virus_1 Acidianus filamentous virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DF6 OCA].
 
==Reference==
<ref group="xtra">PMID:19472363</ref><references group="xtra"/>
[[Category: Acidianus filamentous virus 1]]
[[Category: Acidianus filamentous virus 1]]
[[Category: Cambillau, C.]]
[[Category: Large Structures]]
[[Category: Campanacci, V.]]
[[Category: Cambillau C]]
[[Category: Goulet, A.]]
[[Category: Campanacci V]]
[[Category: Prangishvili, D.]]
[[Category: Goulet A]]
[[Category: Spinelli, S.]]
[[Category: Prangishvili D]]
[[Category: Tilbeurgh, H van.]]
[[Category: Spinelli S]]
[[Category: Archaeal virus]]
[[Category: Van Tilbeurgh H]]
[[Category: Extremophile]]
[[Category: Lipothrixviridae]]
[[Category: Protein fold]]
[[Category: Unknown function]]
[[Category: Viral protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 23 20:21:55 2009''

Latest revision as of 13:40, 16 August 2023

The thermo- and acido-stable ORF-99 from the archaeal virus AFV1The thermo- and acido-stable ORF-99 from the archaeal virus AFV1

Structural highlights

3df6 is a 4 chain structure with sequence from Acidianus filamentous virus 1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.05Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Y099_AFV1Y

Publication Abstract from PubMed

Acidianus Filamentous Virus 1 (AFV1), isolated from acidic hot springs, is an enveloped lipid-containing archaeal filamentous virus with a linear double-stranded DNA genome. It infects Acidianus, which is a hyperthermostable archaea growing at 85 degrees C and acidic pHs, below pH 3. AFV1-99, a protein of 99 amino acids of unknown function, has homologues in the archaeal virus families Lipothrixviridae and Rudiviridae. We determined the crystal structure of AFV1-99 at 2.05 A resolution. AFV1-99 has a new fold, is hyperthermostable (up to 95 degrees C) and resists to extreme pH (between pH 0 and 11) and to the combination of high temperature (95 degrees C) and low pH (pH 0). It possesses characteristics of hyperthermostable proteins, such as a high content of charged residues.

The thermo- and acido-stable ORF-99 from the archaeal virus AFV1.,Goulet A, Spinelli S, Blangy S, van Tilbeurgh H, Leulliot N, Basta T, Prangishvili D, Cambillau C, Campanacci V Protein Sci. 2009 Jun;18(6):1316-20. PMID:19472363[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. ↑ Goulet A, Spinelli S, Blangy S, van Tilbeurgh H, Leulliot N, Basta T, Prangishvili D, Cambillau C, Campanacci V. The thermo- and acido-stable ORF-99 from the archaeal virus AFV1. Protein Sci. 2009 Jun;18(6):1316-20. PMID:19472363 doi:10.1002/pro.122

3df6, resolution 2.05Å

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