2x7h: Difference between revisions

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[[Image:2x7h.jpg|left|200px]]


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==Crystal structure of the human MGC45594 gene product in complex with fenoprofen==
The line below this paragraph, containing "STRUCTURE_2x7h", creates the "Structure Box" on the page.
<StructureSection load='2x7h' size='340' side='right'caption='[[2x7h]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2x7h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X7H FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PFN:FENOPROFEN'>PFN</scene></td></tr>
{{STRUCTURE_2x7h|  PDB=2x7h  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7h OCA], [https://pdbe.org/2x7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x7h RCSB], [https://www.ebi.ac.uk/pdbsum/2x7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x7h ProSAT]</span></td></tr>
 
</table>
===CRYSTAL STRUCTURE OF THE HUMAN MGC45594 GENE PRODUCT IN COMPLEX WITH FENOPROFEN===
== Function ==
 
[https://www.uniprot.org/uniprot/PTGR3_HUMAN PTGR3_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.[UniProtKB:Q8BGC4]
 
__TOC__
==About this Structure==
</StructureSection>
2X7H is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7H OCA].  
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C.]]
[[Category: Large Structures]]
[[Category: Bountra, C.]]
[[Category: Arrowsmith C]]
[[Category: Chaikuad, A.]]
[[Category: Bountra C]]
[[Category: Edwards, A.]]
[[Category: Chaikuad A]]
[[Category: Niesen, F.]]
[[Category: Edwards A]]
[[Category: Oppermann, U.]]
[[Category: Niesen F]]
[[Category: Pike, A C.W.]]
[[Category: Oppermann U]]
[[Category: Shafqat, N.]]
[[Category: Pike ACW]]
[[Category: Smee, C.]]
[[Category: Shafqat N]]
[[Category: Ugochukwu, E.]]
[[Category: Smee C]]
[[Category: Vollmar, M.]]
[[Category: Ugochukwu E]]
[[Category: Vondelft, F.]]
[[Category: Vollmar M]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Yue, W W.]]
[[Category: Yue WW]]
[[Category: Oxidoreductase]]
[[Category: Von Delft F]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec  8 11:45:23 2010''

Latest revision as of 13:37, 16 August 2023

Crystal structure of the human MGC45594 gene product in complex with fenoprofenCrystal structure of the human MGC45594 gene product in complex with fenoprofen

Structural highlights

2x7h is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.6Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PTGR3_HUMAN Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.[UniProtKB:Q8BGC4]

2x7h, resolution 1.60Å

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