4nc3: Difference between revisions
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==Crystal structure of the 5-HT2B receptor solved using serial femtosecond crystallography in lipidic cubic phase.== | ==Crystal structure of the 5-HT2B receptor solved using serial femtosecond crystallography in lipidic cubic phase.== | ||
<StructureSection load='4nc3' size='340' side='right' caption='[[4nc3]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='4nc3' size='340' side='right'caption='[[4nc3]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4nc3]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4nc3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NC3 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=ERM:ERGOTAMINE'>ERM</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=ERM:ERGOTAMINE'>ERM</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nc3 OCA], [https://pdbe.org/4nc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nc3 RCSB], [https://www.ebi.ac.uk/pdbsum/4nc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nc3 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/5HT2B_HUMAN 5HT2B_HUMAN] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[5-hydroxytryptamine receptor|5-hydroxytryptamine receptor]] | *[[5-hydroxytryptamine receptor 3D structures|5-hydroxytryptamine receptor 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli]] | ||
[[Category: Barty | [[Category: Homo sapiens]] | ||
[[Category: Basu | [[Category: Large Structures]] | ||
[[Category: Beyerlein | [[Category: Barty A]] | ||
[[Category: Boutet | [[Category: Basu S]] | ||
[[Category: Caffrey | [[Category: Beyerlein KR]] | ||
[[Category: Chapman | [[Category: Boutet S]] | ||
[[Category: Cherezov | [[Category: Caffrey M]] | ||
[[Category: Fromme | [[Category: Chapman HN]] | ||
[[Category: Fromme | [[Category: Cherezov V]] | ||
[[Category: Fromme P]] | |||
[[Category: Gati | [[Category: Fromme R]] | ||
[[Category: Grotjohann | [[Category: Gati C]] | ||
[[Category: Han | [[Category: Grotjohann I]] | ||
[[Category: James | [[Category: Han GW]] | ||
[[Category: Katritch | [[Category: James D]] | ||
[[Category: Kirian | [[Category: Katritch V]] | ||
[[Category: Koglin | [[Category: Kirian RA]] | ||
[[Category: Kupitz | [[Category: Koglin JE]] | ||
[[Category: Li | [[Category: Kupitz C]] | ||
[[Category: Liu | [[Category: Li D]] | ||
[[Category: Messerschmidt | [[Category: Liu W]] | ||
[[Category: Nelson | [[Category: Messerschmidt M]] | ||
[[Category: Rendek | [[Category: Nelson G]] | ||
[[Category: Seibert | [[Category: Rendek KN]] | ||
[[Category: Shah | [[Category: Seibert MM]] | ||
[[Category: Spence | [[Category: Shah STA]] | ||
[[Category: Stevens | [[Category: Spence JCH]] | ||
[[Category: Wacker | [[Category: Stevens RC]] | ||
[[Category: Wang | [[Category: Wacker D]] | ||
[[Category: Wang | [[Category: Wang C]] | ||
[[Category: Weierstall | [[Category: Wang D]] | ||
[[Category: White | [[Category: Weierstall U]] | ||
[[Category: Williams | [[Category: White TA]] | ||
[[Category: Zatsepin | [[Category: Williams GJ]] | ||
[[Category: Zatsepin NA]] | |||