1qr4: Difference between revisions
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<StructureSection load='1qr4' size='340' side='right'caption='[[1qr4]], [[Resolution|resolution]] 2.55Å' scene=''> | <StructureSection load='1qr4' size='340' side='right'caption='[[1qr4]], [[Resolution|resolution]] 2.55Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1qr4]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1qr4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QR4 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qr4 OCA], [https://pdbe.org/1qr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qr4 RCSB], [https://www.ebi.ac.uk/pdbsum/1qr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qr4 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/TENA_CHICK TENA_CHICK] Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Gallus gallus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bisig | [[Category: Bisig DA]] | ||
[[Category: Piontek | [[Category: Piontek K]] | ||
Latest revision as of 13:05, 16 August 2023
TWO FIBRONECTIN TYPE-III DOMAIN SEGMENT FROM CHICKEN TENASCINTWO FIBRONECTIN TYPE-III DOMAIN SEGMENT FROM CHICKEN TENASCIN
Structural highlights
FunctionTENA_CHICK Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedA fragment of chicken tenascin consisting of fibronectin type-III domains 5 and 6 has been expressed in Escherichia coli. After modifying a previously reported purification protocol, an electrophoretically homogeneous recombinant protein was obtained from which various crystal forms could be grown under identical conditions. Only one form was suitable for structure determination. These crystals belong to space group P21, with unit-cell parameters a = 45.2, b = 57.9, c = 72.2 A, beta = 91.4 degrees, and diffract to at least 2.6 A resolution using synchrotron radiation. From density measurements of the crystals, it was found that there are two molecules in the asymmetric unit. Diffraction data of native, two platinum-derivative and one palladium-derivative crystals were collected. Purification, crystallization and preliminary crystallographic studies of a two fibronectin type-III domain segment from chicken tenascin encompassing the heparin- and contactin-binding regions.,Bisig D, Weber P, Vaughan L, Winterhalter KH, Piontek K Acta Crystallogr D Biol Crystallogr. 1999 May;55(Pt 5):1069-73. PMID:10216309[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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