1pl9: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
No edit summary
No edit summary
 
(11 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1pl9.gif|left|200px]]


{{Structure
==Crystal structure of KDO8P synthase in its binary complex with substrate analog Z-FPEP==
|PDB= 1pl9 |SIZE=350|CAPTION= <scene name='initialview01'>1pl9</scene>, resolution 2.9&Aring;
<StructureSection load='1pl9' size='340' side='right'caption='[[1pl9]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=FPE:3-FLUORO-2-(PHOSPHONOOXY)PROPANOIC+ACID'>FPE</scene>
<table><tr><td colspan='2'>[[1pl9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PL9 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-deoxy-8-phosphooctulonate_synthase 3-deoxy-8-phosphooctulonate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.55 2.5.1.55] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
|GENE= KDSA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPE:3-FLUORO-2-(PHOSPHONOOXY)PROPANOIC+ACID'>FPE</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pl9 OCA], [https://pdbe.org/1pl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pl9 RCSB], [https://www.ebi.ac.uk/pdbsum/1pl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pl9 ProSAT]</span></td></tr>
|RELATEDENTRY=[[1g7u|1G7U]], [[1d9e|1D9E]], [[1phq|1PHQ]], [[1phw|1PHW]], [[1q3n|1Q3N]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pl9 OCA], [http://www.ebi.ac.uk/pdbsum/1pl9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pl9 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/KDSA_ECOLI KDSA_ECOLI] Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth.[HAMAP-Rule:MF_00056]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/1pl9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pl9 ConSurf].
<div style="clear:both"></div>


'''Crystal structure of KDO8P synthase in its binary complex with substrate analog Z-FPEP'''
==See Also==
 
*[[Kdo-8-phosphate synthase|Kdo-8-phosphate synthase]]
 
__TOC__
==About this Structure==
</StructureSection>
1PL9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL9 OCA].
[[Category: 3-deoxy-8-phosphooctulonate synthase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Adir, N.]]
[[Category: Adir N]]
[[Category: Baasov, T.]]
[[Category: Baasov T]]
[[Category: Belakhov, V.]]
[[Category: Belakhov V]]
[[Category: Rabkin, E.]]
[[Category: Rabkin E]]
[[Category: Vainer, R.]]
[[Category: Vainer R]]
[[Category: beta-alpha-barrel]]
[[Category: flourinated analog]]
[[Category: lipopolysaccharide]]
[[Category: lyase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:01:16 2008''

Latest revision as of 12:45, 16 August 2023

Crystal structure of KDO8P synthase in its binary complex with substrate analog Z-FPEPCrystal structure of KDO8P synthase in its binary complex with substrate analog Z-FPEP

Structural highlights

1pl9 is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KDSA_ECOLI Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth.[HAMAP-Rule:MF_00056]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1pl9, resolution 2.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA