1phq: Difference between revisions

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[[Image:1phq.jpg|left|200px]]


{{Structure
==Crystal structure of KDO8P synthase in its binary complex with substrate analog E-FPEP==
|PDB= 1phq |SIZE=350|CAPTION= <scene name='initialview01'>1phq</scene>, resolution 2.7&Aring;
<StructureSection load='1phq' size='340' side='right'caption='[[1phq]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=FPE:3-FLUORO-2-(PHOSPHONOOXY)PROPANOIC ACID'>FPE</scene>
<table><tr><td colspan='2'>[[1phq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PHQ FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/3-deoxy-8-phosphooctulonate_synthase 3-deoxy-8-phosphooctulonate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.55 2.5.1.55]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
|GENE= KDSA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPE:3-FLUORO-2-(PHOSPHONOOXY)PROPANOIC+ACID'>FPE</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1phq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1phq OCA], [https://pdbe.org/1phq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1phq RCSB], [https://www.ebi.ac.uk/pdbsum/1phq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1phq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KDSA_ECOLI KDSA_ECOLI] Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth.[HAMAP-Rule:MF_00056]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ph/1phq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1phq ConSurf].
<div style="clear:both"></div>


'''Crystal structure of KDO8P synthase in its binary complex with substrate analog E-FPEP'''
==See Also==
 
*[[Kdo-8-phosphate synthase|Kdo-8-phosphate synthase]]
 
__TOC__
==About this Structure==
</StructureSection>
1PHQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PHQ OCA].
[[Category: 3-deoxy-8-phosphooctulonate synthase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Adir, N.]]
[[Category: Adir N]]
[[Category: Baasov, T.]]
[[Category: Baasov T]]
[[Category: Belakhov, V.]]
[[Category: Belakhov V]]
[[Category: Rabkin, E.]]
[[Category: Rabkin E]]
[[Category: Vainer, R.]]
[[Category: Vainer R]]
[[Category: FPE]]
[[Category: beta-alpha-barrel]]
[[Category: fluorinated analog]]
[[Category: lipopolysaccharide]]
[[Category: lyase]]
 
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