1os2: Difference between revisions

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-[[Image:1os2.jpg|left|200px]]
-<!--
+==Ternary enzyme-product-inhibitor complexes of human MMP12==
-The line below this paragraph, containing "STRUCTURE_1os2", creates the "Structure Box" on the page.
+<StructureSection load='1os2' size='340' side='right'caption='[[1os2]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1os2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OS2 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HAE:ACETOHYDROXAMIC+ACID'>HAE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_1os2|  PDB=1os2  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1os2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1os2 OCA], [https://pdbe.org/1os2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1os2 RCSB], [https://www.ebi.ac.uk/pdbsum/1os2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1os2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/1os2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1os2 ConSurf].
+<div style="clear:both"></div>
-'''Ternary enzyme-product-inhibitor complexes of human MMP12'''
+==See Also==
+*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-OS2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OS2 OCA].
-==Reference==
-X-ray structures of binary and ternary enzyme-product-inhibitor complexes of matrix metalloproteinases., Bertini I, Calderone V, Fragai M, Luchinat C, Mangani S, Terni B, Angew Chem Int Ed Engl. 2003 Jun 16;42(23):2673-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12813751 12813751]
 [[Category: Homo sapiens]]
-[[Category: Macrophage elastase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Bertini I]]
-[[Category: Bertini, I.]]
+[[Category: Calderone V]]
-[[Category: Calderone, V.]]
+[[Category: Fragai M]]
-[[Category: Fragai, M.]]
+[[Category: Luchinat C]]
-[[Category: Luchinat, C.]]
+[[Category: Mangani S]]
-[[Category: Mangani, S.]]
+[[Category: Terni B]]
-[[Category: Terni, B.]]
-[[Category: Elastase]]
-[[Category: Hydroxamic acid]]
-[[Category: Matrix metalloproteinase]]
-[[Category: Metallo elastase]]
-[[Category: Mmp12]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:12:58 2008''