1os0: Difference between revisions

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OCA

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 ==Thermolysin with an alpha-amino phosphinic inhibitor==
-<StructureSection load='1os0' size='340' side='right' caption='[[1os0]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+<StructureSection load='1os0' size='340' side='right'caption='[[1os0]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1os0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1no0 1no0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OS0 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1os0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1no0 1no0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OS0 FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0PQ:N-{(2R)-3-[(S)-[(1R)-1-AMINO-2-PHENYLETHYL](HYDROXY)PHOSPHORYL]-2-BENZYLPROPANOYL}-L-PHENYLALANINE'>0PQ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kei|1kei]], [[2tmn|2tmn]], [[1qf0|1qf0]], [[1qf1|1qf1]], [[1qf2|1qf2]], [[1tlp|1tlp]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0PQ:N-{(2R)-3-[(S)-[(1R)-1-AMINO-2-PHENYLETHYL](HYDROXY)PHOSPHORYL]-2-BENZYLPROPANOYL}-L-PHENYLALANINE'>0PQ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1os0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1os0 OCA], [https://pdbe.org/1os0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1os0 RCSB], [https://www.ebi.ac.uk/pdbsum/1os0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1os0 ProSAT]</span></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1os0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1os0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1os0 RCSB], [http://www.ebi.ac.uk/pdbsum/1os0 PDBsum]</span></td></tr>
+</table>
-<table>
+== Function ==
+[https://www.uniprot.org/uniprot/THER_BACTH THER_BACTH] Extracellular zinc metalloprotease.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/1os0_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/1os0_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1os0 ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 26: / Line 28: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1os0" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Thermolysin|Thermolysin]]
+*[[Thermolysin 3D structures|Thermolysin 3D structures]]
 == References ==
 <references/>
@@ Line 34: / Line 37: @@
 </StructureSection>
 [[Category: Bacillus thermoproteolyticus]]
-[[Category: Thermolysin]]
+[[Category: Large Structures]]
-[[Category: Prange, T.]]
+[[Category: Prange T]]
-[[Category: Selkti, M.]]
+[[Category: Selkti M]]
-[[Category: Tomas, A.]]
+[[Category: Tomas A]]
-[[Category: Alpha-amino phosphinic compound]]
-[[Category: Hydrolase]]
-[[Category: Hydrolase-hydrolase inhibitor complex]]
-[[Category: Metal-binding]]
-[[Category: Metalloprotease]]
-[[Category: Neprylisin]]
-[[Category: Protease]]
-[[Category: Secreted]]
-[[Category: Thermolysin]]
-[[Category: Zymogen]]