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[[Image:1o5k.gif|left|200px]]<br /><applet load="1o5k" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1o5k, resolution 1.80&Aring;" />
'''Crystal structure of Dihydrodipicolinate synthase (TM1521) from Thermotoga maritima at 1.80 A resolution'''<br />


==About this Structure==
==Crystal structure of Dihydrodipicolinate synthase (TM1521) from Thermotoga maritima at 1.80 A resolution==
1O5K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dihydrodipicolinate_synthase Dihydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.52 4.2.1.52] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5K OCA].
<StructureSection load='1o5k' size='340' side='right'caption='[[1o5k]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
[[Category: Dihydrodipicolinate synthase]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[1o5k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O5K FirstGlance]. <br>
[[Category: Thermotoga maritima]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
[[Category: JCSG, Joint.Center.for.Structural.Genomics.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene></td></tr>
[[Category: CA]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5k OCA], [https://pdbe.org/1o5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o5k RCSB], [https://www.ebi.ac.uk/pdbsum/1o5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o5k ProSAT], [https://www.topsan.org/Proteins/JCSG/1o5k TOPSAN]</span></td></tr>
[[Category: dihydrodipicolinate synthase]]
</table>
[[Category: jcsg]]
== Function ==
[[Category: joint center for structural genomics]]
[https://www.uniprot.org/uniprot/DAPA_THEMA DAPA_THEMA] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA) (Probable).<ref>PMID:16872276</ref>
[[Category: lyase]]
== Evolutionary Conservation ==
[[Category: protein structure initiative]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: psi]]
Check<jmol>
[[Category: structural genomics]]
  <jmolCheckbox>
[[Category: tm1521]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o5/1o5k_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o5k ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 11:21:46 2008''
==See Also==
*[[Dihydrodipicolinate synthase|Dihydrodipicolinate synthase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermotoga maritima MSB8]]

Latest revision as of 12:28, 16 August 2023

Crystal structure of Dihydrodipicolinate synthase (TM1521) from Thermotoga maritima at 1.80 A resolutionCrystal structure of Dihydrodipicolinate synthase (TM1521) from Thermotoga maritima at 1.80 A resolution

Structural highlights

1o5k is a 2 chain structure with sequence from Thermotoga maritima MSB8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

DAPA_THEMA Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA) (Probable).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Pearce FG, Perugini MA, McKerchar HJ, Gerrard JA. Dihydrodipicolinate synthase from Thermotoga maritima. Biochem J. 2006 Dec 1;400(2):359-66. PMID:16872276 doi:10.1042/BJ20060771

1o5k, resolution 1.80Å

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