1lnu: Difference between revisions

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-[[Image:1lnu.png|left|200px]]
-{{STRUCTURE_1lnu|  PDB=1lnu  |  SCENE=  }}
+==CRYSTAL STRUCTURE OF CLASS II MHC MOLECULE IAb BOUND TO EALPHA3K PEPTIDE==
+<StructureSection load='1lnu' size='340' side='right'caption='[[1lnu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1lnu]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LNU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LNU FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lnu OCA], [https://pdbe.org/1lnu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lnu RCSB], [https://www.ebi.ac.uk/pdbsum/1lnu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lnu ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HA2B_MOUSE HA2B_MOUSE]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ln/1lnu_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lnu ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+We have solved the crystal structure of the MHCII molecule, IA(b), containing an antigenic variant of the major IA(b)-binding peptide derived from the MHCII IEalpha chain. The four MHC pockets at p1, p4, p6, and p9 that usually bind peptide side chains are largely empty because of alanines in the peptide at these positions. The complex is nevertheless very stable, apparently because of unique alternate interactions between the IA(b) and peptide. In particular, there are multiple additional hydrogen bonds between the N-terminal end of the peptide and the IA(b) alpha chain and an extensive hydrogen bond network involving an asparagine at p7 position of the peptide and the IA(b) beta chain. By using knowledge of the shape and size of the traditional side chain binding pockets and the additional possible interactions, an IA(b) peptide-binding motif can be deduced that agrees well with the sequences of known IA(b)-binding peptides.
-===CRYSTAL STRUCTURE OF CLASS II MHC MOLECULE IAb BOUND TO EALPHA3K PEPTIDE===
+Alternate interactions define the binding of peptides to the MHC molecule IA(b).,Liu X, Dai S, Crawford F, Fruge R, Marrack P, Kappler J Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8820-5. PMID:12084926<ref>PMID:12084926</ref>
-{{ABSTRACT_PUBMED_12084926}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 1lnu" style="background-color:#fffaf0;"></div>
-[[1lnu]] is a 8 chain structure of [[Major histocompatibility complex]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LNU OCA].
 ==See Also==
-*[[Major histocompatibility complex|Major histocompatibility complex]]
+*[[MHC 3D structures|MHC 3D structures]]
+*[[MHC II 3D structures|MHC II 3D structures]]
-==Reference==
+== References ==
-<ref group="xtra">PMID:012084926</ref><references group="xtra"/>
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Crawford, F.]]
+[[Category: Crawford F]]
-[[Category: Dai, S.]]
+[[Category: Dai S]]
-[[Category: Fruge, R.]]
+[[Category: Fruge R]]
-[[Category: Kappler, J.]]
+[[Category: Kappler J]]
-[[Category: Liu, X.]]
+[[Category: Liu X]]
-[[Category: Marrack, P.]]
+[[Category: Marrack P]]
-[[Category: Antigen presentation]]
-[[Category: Protein-peptide complex]]
-[[Category: Sugar binding protein]]
-[[Category: T cell receptor]]