1kmc: Difference between revisions

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OCA

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-[[Image:1kmc.gif|left|200px]]
- {{Structure
+==Crystal Structure of the Caspase-7 / XIAP-BIR2 Complex==
-|PDB= 1kmc |SIZE=350|CAPTION= <scene name='initialview01'>1kmc</scene>, resolution 2.9&Aring;
+<StructureSection load='1kmc' size='340' side='right'caption='[[1kmc]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[1kmc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KMC FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-|GENE=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kmc OCA], [https://pdbe.org/1kmc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kmc RCSB], [https://www.ebi.ac.uk/pdbsum/1kmc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kmc ProSAT]</span></td></tr>
-|DOMAIN=
+</table>
-|RELATEDENTRY=[[1i4o|1I4O]], [[1i51|1I51]], [[1i3o|1I3O]]
+== Function ==
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kmc OCA], [http://www.ebi.ac.uk/pdbsum/1kmc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kmc RCSB]</span>
+[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
-}}
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/1kmc_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kmc ConSurf].
+<div style="clear:both"></div>
-'''Crystal Structure of the Caspase-7 / XIAP-BIR2 Complex'''
+==See Also==
+*[[Caspase 3D structures|Caspase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-KMC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KMC OCA].
 [[Category: Homo sapiens]]
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Bode, W.]]
+[[Category: Bode W]]
-[[Category: Riedl, S J.]]
+[[Category: Riedl SJ]]
-[[Category: Salvesen, G S.]]
+[[Category: Salvesen GS]]
-[[Category: apoptosis]]
-[[Category: bir]]
-[[Category: caspase]]
-[[Category: complex]]
-[[Category: iap]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:50:33 2008''