1kg5: Difference between revisions

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-[[Image:1kg5.gif|left|200px]]
- {{Structure
+==Crystal structure of the K142Q mutant of E.coli MutY (core fragment)==
-|PDB= 1kg5 |SIZE=350|CAPTION= <scene name='initialview01'>1kg5</scene>, resolution 1.35&Aring;
+<StructureSection load='1kg5' size='340' side='right'caption='[[1kg5]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+<table><tr><td colspan='2'>[[1kg5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KG5 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
-|GENE= mutY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kg5 OCA], [https://pdbe.org/1kg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kg5 RCSB], [https://www.ebi.ac.uk/pdbsum/1kg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kg5 ProSAT]</span></td></tr>
-|RELATEDENTRY=[[1kg2|1KG2]], [[1kg3|1KG3]], [[1kg4|1KG4]], [[1kg6|1KG6]], [[1kg7|1KG7]]
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kg5 OCA], [http://www.ebi.ac.uk/pdbsum/1kg5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kg5 RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/MUTY_ECOLI MUTY_ECOLI] Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/1kg5_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kg5 ConSurf].
+<div style="clear:both"></div>
-'''Crystal structure of the K142Q mutant of E.coli MutY (core fragment)'''
+==See Also==
+*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-KG5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KG5 OCA].
 [[Category: Escherichia coli]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Gerchman, S E.]]
+[[Category: Gerchman SE]]
-[[Category: Gilboa, R.]]
+[[Category: Gilboa R]]
-[[Category: Grollman, A P.]]
+[[Category: Grollman AP]]
-[[Category: Kilshtein, A.]]
+[[Category: Kilshtein A]]
-[[Category: Kycia, J H.]]
+[[Category: Kycia JH]]
-[[Category: Shoham, G.]]
+[[Category: Shoham G]]
-[[Category: Zharkov, D O.]]
+[[Category: Zharkov DO]]
-[[Category: dna repair]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:48:08 2008''