1jum: Difference between revisions

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<StructureSection load='1jum' size='340' side='right'caption='[[1jum]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
<StructureSection load='1jum' size='340' side='right'caption='[[1jum]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1jum]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUM FirstGlance]. <br>
<table><tr><td colspan='2'>[[1jum]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JUM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BER:BERBERINE'>BER</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.98&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jt0|1jt0]], [[1jt6|1jt6]], [[1jtx|1jtx]], [[1jty|1jty]], [[1jup|1jup]], [[1jus|1jus]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BER:BERBERINE'>BER</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jum OCA], [http://pdbe.org/1jum PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jum RCSB], [http://www.ebi.ac.uk/pdbsum/1jum PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jum ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jum OCA], [https://pdbe.org/1jum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jum RCSB], [https://www.ebi.ac.uk/pdbsum/1jum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jum ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU]] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.  
[https://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Brennan, R G]]
[[Category: Staphylococcus aureus]]
[[Category: Brown, M H]]
[[Category: Brennan RG]]
[[Category: Grkovic, S]]
[[Category: Brown MH]]
[[Category: Miller, M C]]
[[Category: Grkovic S]]
[[Category: Schumacher, M A]]
[[Category: Miller MC]]
[[Category: Skurray, R A]]
[[Category: Schumacher MA]]
[[Category: Berberine]]
[[Category: Skurray RA]]
[[Category: Multidrug binding]]
[[Category: Multidrug recognition]]
[[Category: Natural drug]]
[[Category: Plant alkaloid]]
[[Category: Qacr]]
[[Category: S. aureus]]
[[Category: Transcription]]

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