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==Crystal Structure of the HPRT from Salmonella typhimurium==
==Crystal Structure of the HPRT from Salmonella typhimurium==
<StructureSection load='1j7j' size='340' side='right' caption='[[1j7j]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='1j7j' size='340' side='right'caption='[[1j7j]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1j7j]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J7J FirstGlance]. <br>
<table><tr><td colspan='2'>[[1j7j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J7J FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j7j OCA], [http://pdbe.org/1j7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1j7j RCSB], [http://www.ebi.ac.uk/pdbsum/1j7j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1j7j ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j7j OCA], [https://pdbe.org/1j7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j7j RCSB], [https://www.ebi.ac.uk/pdbsum/1j7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j7j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HPRT_SALTY HPRT_SALTY]] Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine (By similarity).  
[https://www.uniprot.org/uniprot/HPRT_SALTY HPRT_SALTY] Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j7j ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j7j ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hypoxanthine phosphoribosyltransferase]]
[[Category: Large Structures]]
[[Category: Eakin, A E]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
[[Category: Focia, P J]]
[[Category: Eakin AE]]
[[Category: Lee, C C]]
[[Category: Focia PJ]]
[[Category: Spraggon, G]]
[[Category: Lee CC]]
[[Category: Glycosyltransferase]]
[[Category: Spraggon G]]
[[Category: Nucleotide metabolism]]
[[Category: Phosphoribosyltransferase]]
[[Category: Purine salvage]]
[[Category: Transferase]]

Latest revision as of 11:36, 16 August 2023

Crystal Structure of the HPRT from Salmonella typhimuriumCrystal Structure of the HPRT from Salmonella typhimurium

Structural highlights

1j7j is a 2 chain structure with sequence from Salmonella enterica subsp. enterica serovar Typhimurium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HPRT_SALTY Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1j7j, resolution 2.30Å

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