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[[Image:1j7j.jpg|left|200px]]


{{Structure
==Crystal Structure of the HPRT from Salmonella typhimurium==
|PDB= 1j7j |SIZE=350|CAPTION= <scene name='initialview01'>1j7j</scene>, resolution 2.3&Aring;
<StructureSection load='1j7j' size='340' side='right'caption='[[1j7j]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene>
<table><tr><td colspan='2'>[[1j7j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J7J FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
|GENE= hpt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=602 Salmonella typhimurium])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j7j OCA], [https://pdbe.org/1j7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j7j RCSB], [https://www.ebi.ac.uk/pdbsum/1j7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j7j ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HPRT_SALTY HPRT_SALTY] Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j7/1j7j_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j7j ConSurf].
<div style="clear:both"></div>


'''Crystal Structure of the HPRT from Salmonella typhimurium'''
==See Also==
 
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1J7J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J7J OCA].
[[Category: Large Structures]]
[[Category: Hypoxanthine phosphoribosyltransferase]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
[[Category: Salmonella typhimurium]]
[[Category: Eakin AE]]
[[Category: Single protein]]
[[Category: Focia PJ]]
[[Category: Eakin, A E.]]
[[Category: Lee CC]]
[[Category: Focia, P J.]]
[[Category: Spraggon G]]
[[Category: Lee, C C.]]
[[Category: Spraggon, G.]]
[[Category: MG]]
[[Category: glycosyltransferase]]
[[Category: nucleotide metabolism]]
[[Category: phosphoribosyltransferase]]
[[Category: purine salvage]]
[[Category: transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:59:39 2008''

Latest revision as of 11:36, 16 August 2023

Crystal Structure of the HPRT from Salmonella typhimuriumCrystal Structure of the HPRT from Salmonella typhimurium

Structural highlights

1j7j is a 2 chain structure with sequence from Salmonella enterica subsp. enterica serovar Typhimurium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HPRT_SALTY Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1j7j, resolution 2.30Å

Drag the structure with the mouse to rotate

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OCA
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