5hgi: Difference between revisions

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 ==Crystal structure of apo human IRE1 alpha==
-<StructureSection load='5hgi' size='340' side='right' caption='[[5hgi]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
+<StructureSection load='5hgi' size='340' side='right'caption='[[5hgi]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5hgi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HGI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HGI FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5hgi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HGI FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.584&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hgi OCA], [http://pdbe.org/5hgi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hgi RCSB], [http://www.ebi.ac.uk/pdbsum/5hgi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hgi ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hgi OCA], [https://pdbe.org/5hgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hgi RCSB], [https://www.ebi.ac.uk/pdbsum/5hgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hgi ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/ERN1_HUMAN ERN1_HUMAN]] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:9637683</ref> <ref>PMID:11175748</ref> <ref>PMID:12637535</ref> [UniProtKB:Q9EQY0]
+[https://www.uniprot.org/uniprot/ERN1_HUMAN ERN1_HUMAN] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:9637683</ref> <ref>PMID:11175748</ref> <ref>PMID:12637535</ref> [UniProtKB:Q9EQY0]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 18: / Line 19: @@
 </div>
 <div class="pdbe-citations 5hgi" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Ire1|Ire1]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Backes, B J]]
+[[Category: Homo sapiens]]
-[[Category: Feldman, H C]]
+[[Category: Large Structures]]
-[[Category: Gliedt, J M]]
+[[Category: Backes BJ]]
-[[Category: Gobillot, T A]]
+[[Category: Feldman HC]]
-[[Category: Hari, S B]]
+[[Category: Gliedt JM]]
-[[Category: Maly, D J]]
+[[Category: Gobillot TA]]
-[[Category: Meza-Acevedo, R]]
+[[Category: Hari SB]]
-[[Category: Mitra, A K]]
+[[Category: Maly DJ]]
-[[Category: Papa, F R]]
+[[Category: Meza-Acevedo R]]
-[[Category: Seeliger, M A]]
+[[Category: Mitra AK]]
-[[Category: Tong, M]]
+[[Category: Papa FR]]
-[[Category: Wang, L]]
+[[Category: Seeliger MA]]
-[[Category: Rnase]]
+[[Category: Tong M]]
-[[Category: Ser/thr protein kinase]]
+[[Category: Wang L]]
-[[Category: Transferase-oxidoreductase complex]]