1yu1: Difference between revisions

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==Major Tropism Determinant P3c Variant==
==Major Tropism Determinant P3c Variant==
<StructureSection load='1yu1' size='340' side='right' caption='[[1yu1]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
<StructureSection load='1yu1' size='340' side='right'caption='[[1yu1]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1yu1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpbpp Bpbpp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YU1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1yu1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bordetella_virus_BPP1 Bordetella virus BPP1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YU1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MMC:METHYL+MERCURY+ION'>MMC</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yu0|1yu0]], [[1yu2|1yu2]], [[1yu3|1yu3]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MMC:METHYL+MERCURY+ION'>MMC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yu1 OCA], [http://pdbe.org/1yu1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yu1 RCSB], [http://www.ebi.ac.uk/pdbsum/1yu1 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yu1 OCA], [https://pdbe.org/1yu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yu1 RCSB], [https://www.ebi.ac.uk/pdbsum/1yu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yu1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q775D6_BPBPP Q775D6_BPBPP]] Tail fiber protein located at the distal ends of the fibers that binds to the adhesion receptors on the host surface, thereby determining the host range. The phage can alter its tropism by modifying this protein. Variants are expressed through a diversity-generating retroelement (DGR) that creates mutant copies of a template repeat and replaces the end of the tail fiber receptor-binding protein with these sequences, thus changing the host range. Milliards of variants of the fiber receptor-binding protein can be created with this system.<ref>PMID:15386016</ref>
[https://www.uniprot.org/uniprot/FIBD_BPBPP FIBD_BPBPP] Tail fiber protein located at the distal ends of the fibers that binds to the adhesion receptors on the host surface, thereby determining the host range. The phage can alter its tropism by modifying this protein. Variants are expressed through a diversity-generating retroelement (DGR) that creates mutant copies of a template repeat and replaces the end of the tail fiber receptor-binding protein with these sequences, thus changing the host range. Milliards of variants of the fiber receptor-binding protein can be created with this system.<ref>PMID:15386016</ref>  
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bpbpp]]
[[Category: Bordetella virus BPP1]]
[[Category: Ghosh, P]]
[[Category: Large Structures]]
[[Category: Lawton, J A]]
[[Category: Ghosh P]]
[[Category: McMahon, S A]]
[[Category: Lawton JA]]
[[Category: Miller, J L]]
[[Category: McMahon SA]]
[[Category: Beta prism]]
[[Category: Miller JL]]
[[Category: Beta sandwich]]
[[Category: C-type lectin]]
[[Category: Diversity-generating retroelement]]
[[Category: Variability]]
[[Category: Viral protein]]

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