8d9x: Difference between revisions

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-'''Unreleased structure'''
-The entry 8d9x is ON HOLD
+==Cryo-EM structure of human DELE1 in oligomeric form==
+<StructureSection load='8d9x' size='340' side='right'caption='[[8d9x]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
-Authors: Yang, J., Lander, G.C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8d9x]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D9X FirstGlance]. <br>
-Description: Cryo-EM structure of human DELE1 in oligomeric form
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d9x OCA], [https://pdbe.org/8d9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d9x RCSB], [https://www.ebi.ac.uk/pdbsum/8d9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d9x ProSAT]</span></td></tr>
-[[Category: Yang, J]]
+</table>
-[[Category: Lander, G.C]]
+== Function ==
+[https://www.uniprot.org/uniprot/DELE1_HUMAN DELE1_HUMAN] Key activator of the integrated stress response (ISR) following mitochondrial stress (PubMed:32132706, PubMed:32132707). In response to mitochondrial stress, cleaved by the protease OMA1, generating the DAP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (PubMed:32132706, PubMed:32132707). Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation (PubMed:20563667).<ref>PMID:20563667</ref> <ref>PMID:32132706</ref> <ref>PMID:32132707</ref>   Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI (PubMed:32132706, PubMed:32132707). It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR (PubMed:32132706, PubMed:32132707).<ref>PMID:32132706</ref> <ref>PMID:32132707</ref> [https://www.uniprot.org/uniprot/A0A376KDN7_ECOLX A0A376KDN7_ECOLX] Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins.[RuleBase:RU365005]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Lander GC]]
+[[Category: Yang J]]