7xtp: Difference between revisions
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New page: '''Unreleased structure''' The entry 7xtp is ON HOLD Authors: Brown, C.J., Frosi, Y., Jiang, S., Lin, Y.C. Description: eIF4E in Complex with a Disulphide-Free Autonomous VH Domain [[C... |
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==eIF4E in Complex with a Disulphide-Free Autonomous VH Domain== | |||
<StructureSection load='7xtp' size='340' side='right'caption='[[7xtp]], [[Resolution|resolution]] 1.83Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7xtp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XTP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.828Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGO:[[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL]+PHOSPHONO+HYDROGEN+PHOSPHATE'>MGO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xtp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xtp OCA], [https://pdbe.org/7xtp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xtp RCSB], [https://www.ebi.ac.uk/pdbsum/7xtp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xtp ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref> | |||
==See Also== | |||
*[[Antibody 3D structures|Antibody 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Brown | __TOC__ | ||
[[Category: Frosi | </StructureSection> | ||
[[Category: Jiang | [[Category: Homo sapiens]] | ||
[[Category: Lin | [[Category: Large Structures]] | ||
[[Category: Brown CJ]] | |||
[[Category: Frosi Y]] | |||
[[Category: Jiang S]] | |||
[[Category: Lin YC]] | |||
Latest revision as of 09:55, 9 August 2023
eIF4E in Complex with a Disulphide-Free Autonomous VH DomaineIF4E in Complex with a Disulphide-Free Autonomous VH Domain
Structural highlights
FunctionIF4E_HUMAN Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.[1] See AlsoReferences
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